Functional connectivity of the dorsal and median raphe nuclei at rest.
Functional connectivity of the dorsal and median raphe nuclei at rest.
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DOI：
10.1016/j.neuroimage.2015.04.065
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发表时间：
2015-08-01
期刊：
影响因子：
5.7
通讯作者：
Fisher PM
中科院分区：
文献类型：
--
作者：
Beliveau V;Svarer C;Frokjaer VG;Knudsen GM;Greve DN;Fisher PM
5-羟色胺（5-HT）是一种神经递质，与广泛的脑功能密切相关，并与神经精神疾病（包括重度抑郁症、焦虑症和睡眠障碍）的病理生理学有关。尽管5-HT广泛分布于整个大脑，但对5-HT对内在大脑活动的贡献的了解有限。中缝背核（DR）和中缝正中核（MR）是大多数投射到整个大脑的多巴胺能神经元的来源，因此为基于种子的5-HT相关静息态活动探针提供了一个引人注目的靶点。在这里，我们实施了一种新的多模态神经成像方法，用于研究DR和MR与皮质，皮质下和小脑目标区域之间的静息状态功能连接（FC）。使用[11 C]DASB正电子发射断层扫描（PET）图像的脑5-羟色胺转运蛋白（5-HTT）结合结构MRI从49名健康志愿者，我们划定DR和MR，并进行了种子为基础的静息状态FC分析。DR和MR种子产生了很大程度上相似的FC图：显著的阳性FC与涉及认知和情感处理的脑区，包括前扣带回、杏仁核、海马、丘脑、基底神经节和小脑。在DR的中央前回和中央后回内观察到显著的负FC，但MR种子未观察到。我们观察到DR和MR FC与区域5-HTT结合之间存在显著相关性。我们的研究结果提供了一个与DR和MR相关的静息态网络的证据，该网络包括接受多巴胺能神经支配的区域，并集中参与5-HT相关行为，包括情绪，认知和奖励处理。这些发现为估计与5-HT信号相关的静息态FC提供了新的进展，这有助于我们理解其在行为和神经精神疾病中的作用。
Serotonin (5-HT) is a neurotransmitter critically involved in a broad range of brain functions and implicated in the pathophysiology of neuropsychiatric illnesses including major depression, anxiety and sleep disorders. Despite being widely distributed throughout the brain, there is limited knowledge on the contribution of 5-HT to intrinsic brain activity. The dorsal raphe (DR) and median raphe (MR) nuclei are the source of most serotonergic neurons projecting throughout the brain and thus provide a compelling target for a seed-based probe of resting-state activity related to 5-HT. Here we implemented a novel multimodal neuroimaging approach for investigating resting-state functional connectivity (FC) between DR and MR and cortical, subcortical and cerebellar target areas. Using [11C]DASB positron emission tomography (PET) images of the brain serotonin transporter (5-HTT) combined with structural MRI from 49 healthy volunteers, we delineated DR and MR and performed a seed-based resting-state FC analysis. The DR and MR seeds produced largely similar FC maps: significant positive FC with brain regions involved in cognitive and emotion processing including anterior cingulate, amygdala, insula, hippocampus, thalamus, basal ganglia and cerebellum. Significant negative FC was observed within pre- and postcentral gyri for the DR but not for the MR seed. We observed a significant association between DR and MR FC and regional 5-HTT binding. Our results provide evidence for a resting-state network related to DR and MR and comprising regions receiving serotonergic innervation and centrally involved in 5-HT related behaviors including emotion, cognition and reward processing. These findings provide a novel advance in estimating resting-state FC related to 5-HT signaling, which can benefit our understanding of its role in behavior and neuropsychiatric illnesses.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
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2.9
作者：
Brooks JC;Faull OK;Pattinson KT;Jenkinson M
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Jenkinson M
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5.7
作者：
Beall, Erik B.;Lowe, Mark J.
通讯作者：
Lowe, Mark J.
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作者：
BAKER, KG;HALLIDAY, GM;TORK, I
通讯作者：
TORK, I
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作者：
Beall, Erik B.
通讯作者：
Beall, Erik B.