A kinetic model unifying presynaptic short-term facilitation and depression.
A kinetic model unifying presynaptic short-term facilitation and depression.
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DOI：
10.1007/s10827-008-0122-6
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发表时间：
2009-06
影响因子：
1.2
通讯作者：
McRae, Gregory J.
中科院分区：
文献类型：
--
作者：
Lee, Chuang-Chung J.;Anton, Mihai;Poon, Chi-Sang;McRae, Gregory J.
短时程易化和抑制是指在毫秒到秒的时间尺度内，在重复刺激下突触强度的增加和减少。这种现象主要归因于突触前机制，如钙依赖性递质释放和突触前囊泡耗竭。以前的建模研究，旨在整合复杂的短期促进和短期抑郁的数据来自不同的突触依赖于计算机模拟或抽象的数学方法。在这里，我们提出了一个统一的理论突触短期可塑性的基础上现实的，但易于处理和可测试的模型描述的基本细胞内的生化过程。模型方程的分析导致一个封闭形式的解决方案的共振频率，几个关键的生物物理参数的函数，作为单一的关键指标的倾向，突触促进或抑郁症下重复刺激。这一整合模型得到了广泛的瞬态和频率响应实验数据的支持，包括那些从促进，抑制或混合模式突触。具体地说，该理论预测，高钙初始浓度和钙作用的大增益导致低共振频率，因此抑制行为。相比之下，对于对钙不太敏感或恢复率较高的突触，共振频率变得更高，从而易化盛行。共振频率的概念，因此允许有价值的定量参数评估的贡献，各种突触前机制的突触短期可塑性的方向性。因此，该模型提供了在实验中观察到的易化和抑郁之间的切换行为背后的原因。通过调节共振频率和共振带宽来控制短时程突触信号处理的新实验也被提出。
Short-term facilitation and depression refer to the increase and decrease of synaptic strength under repetitive stimuli within a timescale of milliseconds to seconds. This phenomenon has been attributed to primarily presynaptic mechanisms such as calcium-dependent transmitter release and presynaptic vesicle depletion. Previous modeling studies that aimed to integrate the complex short-term facilitation and short-term depression data derived from varying synapses have relied on computer simulation or abstract mathematical approaches. Here, we propose a unified theory of synaptic short-term plasticity based on realistic yet tractable and testable model descriptions of the underlying intracellular biochemical processes. Analysis of the model equations leads to a closed-form solution of the resonance frequency, a function of several critical biophysical parameters, as the single key indicator of the propensity for synaptic facilitation or depression under repetitive stimuli. This integrative model is supported by a broad range of transient and frequency response experimental data including those from facilitating, depressing or mixed-mode synapses. Specifically, the theory predicts that high calcium initial concentration and large gain of calcium action result in low resonance frequency and hence depressing behavior. In contrast, for synapses that are less sensitive to calcium or have higher recovery rate, resonance frequency becomes higher and thus facilitation prevails. The notion of resonance frequency therefore allows valuable quantitative parametric assessment of the contributions of various presynaptic mechanisms to the directionality of synaptic short-term plasticity. Thus, the model provides the reasons behind the switching behavior between facilitation and depression observed in experiments. New experiments are also suggested to control the short-term synaptic signal processing through adjusting the resonance frequency and bandwidth.
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影响因子：
16.2
作者：
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通讯作者：
Herlitze, Stefan
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作者：
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通讯作者：
Zilberter, Y