Research priorities for the discovery of a cure for chronic hepatitis B: Report of a workshop.

Research priorities for the discovery of a cure for chronic hepatitis B: Report of a workshop.
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DOI:
10.1016/j.antiviral.2017.12.006
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发表时间:
2018-03
期刊:
影响因子:
7.6
通讯作者:
Shetty K
Shetty K
中科院分区:
医学2区
文献类型:
--
作者:
Block TM;Alter H;Brown N;Brownstein A;Brosgart C;Chang KM;Chen PJ;Cohen C;El-Serag H;Feld J;Gish R;Glenn J;Greten TF;Guo JT;Hoshida Y;Kowdley KV;Li W;Lok AS;McMahon B;Mehta A;Perrillo R;Rice CM;Rinaudo J;Schinazi RF;Shetty K

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2017年初,B型肝炎基金会邀请了30位B型肝炎和肝癌研究领域的专家,以确定他们认为对找到慢性B和D型肝炎以及与这些病毒感染相关的疾病的治愈方法的目标至关重要的项目。还要求它们确定研究的一般类别,并确定这些领域内次级项目专题的优先次序。专家们普遍同意广泛定义的研究领域,但得分最高和最低的项目之间通常没有什么区别;在大多数情况下,本文件中描述的所有项目都被认为是有价值和必要的。最近发表了这次讨论的执行摘要。本稿报告了讲习班与会者确定的研究领域,简要说明了选择这些领域的理由,并试图在每个研究领域的优先次序有所不同时加以说明。
In early 2017, the Hepatitis B Foundation invited 30 experts in the fields of hepatitis B and liver cancer research to identify projects they deemed important to the goal of finding a cure for chronic hepatitis B and D and the diseases with which these viral infections are associated. They were also asked to identify general categories of research and to prioritize sub-project topics within those areas. The experts generally agreed on broadly defined areas of research, but there was usually little difference between the highest and lowest scoring projects; for the most part, all programs described in this document were considered valuable and necessary. An executive summary of this discussion was recently published. The present manuscript reports the areas of research identified by the workshop participants, provides a brief rationale for their selection, and attempts to express differences among the priorities assigned to each area of research, when such distinctions were expressed.
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