Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment.
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment.
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DOI：
10.1002/emmm.201100159
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发表时间：
2011-09
影响因子：
11.1
通讯作者：
Burcelin, Remy
中科院分区：
文献类型：
--
作者：
Amar, Jacques;Chabo, Chantal;Waget, Aurelie;Klopp, Pascale;Vachoux, Christelle;Bermudez-Humaran, Luis G.;Smirnova, Natalia;Berge, Mathieu;Sulpice, Thierry;Lahtinen, Sampo;Ouwehand, Arthur;Langella, Philippe;Rautonen, Nina;Sansonetti, Philippe J.;Burcelin, Remy
关键词：
富含脂肪的饮食会改变肠道微生物群，引发低度炎症、胰岛素抵抗和2型糖尿病。在这里，我们证明了在糖尿病发作之前，仅经过一周的高脂肪饮食（HFD），活的肠道细菌大量存在于脂肪组织和血液中，它们可以诱导炎症。这种易位在缺乏微生物模式识别受体Nod 1或CD 14的小鼠中被阻止，但在Myd 88敲除和ob/ob小鼠中明显增加。这种“代谢菌血症”的特征在于与来自肠固有层的树突状细胞的共定位增加以及非致病性大肠杆菌的肠粘膜粘附增强。从肠道到组织的细菌移位过程可以通过用益生菌菌株动物双歧杆菌亚种治疗六周来逆转。乳酸420，其改善动物的总体炎症和代谢状态。总而言之，这些数据表明，HFD诱导的高血糖症的早期发作的特征是细菌从肠道向组织的移位增加，加剧了持续的代谢菌血症，这可能代表新的治疗靶点。
A fat-enriched diet modifies intestinal microbiota and initiates a low-grade inflammation, insulin resistance and type-2 diabetes. Here, we demonstrate that before the onset of diabetes, after only one week of a high-fat diet (HFD), live commensal intestinal bacteria are present in large numbers in the adipose tissue and the blood where they can induce inflammation. This translocation is prevented in mice lacking the microbial pattern recognition receptors Nod1 or CD14, but overtly increased in Myd88 knockout and ob/ob mouse. This ‘metabolic bacteremia’ is characterized by an increased co-localization with dendritic cells from the intestinal lamina propria and by an augmented intestinal mucosal adherence of non-pathogenic Escherichia coli. The bacterial translocation process from intestine towards tissue can be reversed by six weeks of treatment with the probiotic strain Bifidobacterium animalis subsp. lactis 420, which improves the animals' overall inflammatory and metabolic status. Altogether, these data demonstrate that the early onset of HFD-induced hyperglycemia is characterized by an increased bacterial translocation from intestine towards tissues, fuelling a continuous metabolic bacteremia, which could represent new therapeutic targets.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
DOI：
10.1152/ajpendo.00332.2001
发表时间：
2002-04-01
影响因子：
5.1
作者：
Burcelin, M;Crivelli, V;Thorens, B
通讯作者：
Thorens, B
影响因子：
64.8
作者：
Fukuda, Shinji;Toh, Hidehiro;Ohno, Hiroshi
通讯作者：
Ohno, Hiroshi
影响因子：
4.4
作者：
Bermudez-Humaran, Luis G.;Nouaille, Sebastien;Issad, Tarik
通讯作者：
Issad, Tarik
DOI：
10.1073/pnas.0504978102
发表时间：
2005-08-02
影响因子：
11.1
作者：
Ley, RE;Bäckhed, F;Gordon, JI
通讯作者：
Gordon, JI