The relative importance of genetics and phenotypic plasticity in dictating bone morphology and mechanics in aged mice: evidence from an artificial selection experiment.
The relative importance of genetics and phenotypic plasticity in dictating bone morphology and mechanics in aged mice: evidence from an artificial selection experiment.
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遗传学和表型可塑性在决定老年小鼠骨形态和力学方面的相对重要性：来自人工选择实验的证据。
DOI：
10.1016/j.zool.2007.06.003
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Swartz,SharonM
中科院分区：
文献类型：
--
作者：
Middleton,KevinM;Shubin,CorinneE;Moore,DouglasC;Carter,PatrickA;GarlandJr,Theodore;Swartz,SharonM
已知遗传和环境因素都会影响骨的结构，从而影响骨在加载过程中的力学行为和对加载的适应性反应。我们介绍了一种新的方法，同时解决遗传介导的，运动相关的影响骨形态计量学和强度，使用小鼠，已被选择性地培育高水平的自愿轮运行（16代）。从高运行和控制线的雌性小鼠被允许（n=12，12，分别）或拒绝（n=11，12，分别）访问轮20个月。使用卡尺和微型计算机断层扫描测量股骨干、股骨颈和股骨头。在悬臂弯曲中评估股骨头的骨折特征。通过双向协方差分析调整体重变化后，股骨远端宽度因选择性繁殖而增加，而股骨内外径因车轮进入而减少。股骨中段的横截面积显示出显著的线型×活动效应，在高跑步线中随着车轮进入而增加，但在对照线中减少。体重与许多形态测量学性状的研究显着正相关。股骨颈的形态特征对股骨颈的骨折负荷有很强的正向预测作用（r2>0.30），但没有发现选择性繁殖或车轮进入的显著影响。体重与股骨形态特征的显著相关性强调了在分析骨大小和形状对实验治疗的反应时控制体重的重要性。在控制体重后，股骨颈的测量仍然是股骨颈强度的重要预测因素。
Both genetic and environmental factors are known to influence the structure of bone, contributing to its mechanical behavior during, and adaptive response to, loading. We introduce a novel approach to simultaneously address the genetically mediated, exercise-related effects on bone morphometrics and strength, using mice that had been selectively bred for high levels of voluntary wheel running (16 generations). Female mice from high running and control lines were either allowed (n=12, 12, respectively) or denied (n=11, 12, respectively) access to wheels for 20 months. Femoral shaft, neck, and head were measured with calipers and via micro-computed tomography. Fracture characteristics of the femoral head were assessed in cantilever bending. After adjusting for variation in body mass by two-way analysis of covariance, distal width of the femur increased as a result of selective breeding, and mediolateral femoral diameter was reduced by wheel access. Cross-sectional area of the femoral mid-shaft showed a significant linetype × activity effect, increasing with wheel access in high-running lines but decreasing in control lines. Body mass was significantly positively correlated with many of the morphometric traits studied. Fracture load of the femoral neck was strongly positively predicted by morphometric traits of the femoral neck (r2>0.30), but no significant effects of selective breeding or wheel access were found. The significant correlations of body mass with femoral morphometric traits underscore the importance of controlling for body size when analyzing the response of bone size and shape to experimental treatments. After controlling for body mass, measures of the femoral neck remain significant predictors of femoral neck strength.
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影响因子：
12.3
作者：
Regenberg B;Grotkjaer T;Winther O;Fausbøll A;Akesson M;Bro C;Hansen LK;Brunak S;Nielsen J
通讯作者：
Nielsen J
小型兽类哺乳动物在平地上运动时四肢的扭矩模式。
影响因子：
2.8
作者：
H. Witte;J. Biltzinger;R. Hackert;N. Schilling;Manuela Schmidt;Christian Reich;M. Fischer
通讯作者：
M. Fischer
影响因子：
6.2
作者：
Järvinen, TLN;Pajamäki, I;Kannus, P
通讯作者：
Kannus, P
影响因子：
2.8
作者：
C. Ruff;E. Trinkaus;E. Trinkaus;A. Walker;C. Larsen
通讯作者：
C. Ruff;E. Trinkaus;E. Trinkaus;A. Walker;C. Larsen
影响因子：
2.6
作者：
Gnudi, S;Ripamonti, C;Malavolta, N
通讯作者：
Malavolta, N