The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude.
The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude.
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DOI：
10.1289/ehp.9937
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发表时间：
2007-08
影响因子：
10.4
通讯作者：
Jones G
中科院分区：
文献类型：
--
作者：
van der Mei IA;Ponsonby AL;Engelsen O;Pasco JA;McGrath JJ;Eyles DW;Blizzard L;Dwyer T;Lucas R;Jones G
日照不足和饮食中维生素D摄入不足会导致维生素D不足。然而，关于不同地区和季节健康个体的实际维生素D状况和预测因素的数据有限。我们比较了维生素D状态[25-羟基维生素D；25(OH)D]在60岁以下人群中使用来自澳大利亚三个地区的横断面研究数据：昆士兰东南部（27°S； 167名女性和211名男性），吉朗地区（38°S； 561名女性）和塔斯马尼亚（43°S； 432名女性和298名男性）。冬季/春季女性维生素D不足（≤50 nmol/L）的患病率在昆士兰东南部为40.5%，在吉隆地区为37.4%，在塔斯马尼亚州为67.3%。季节，模拟维生素D合成的最大每日持续时间，维生素D有效日剂量各解释了25(OH)D变化的14%左右。虽然纬度只解释了3.9%的变化，但纬度每增加1度，平均25(OH)D下降1.0(95%可信区间，0.7-1.3)nmol/L可能与临床相关。在某些月份，我们发现根据模拟紫外线指数建议进行日晒防护时存在高度不足甚至不足。在澳大利亚，维生素D缺乏在广泛的纬度范围内很常见。季节似乎比纬度更重要，但两者都占血清25(OH)D水平变化的不到五分之一，突出了行为因素的重要性。目前的日光照射指南似乎并不能完全预防维生素D不足，应该考虑对其进行修改或寻求其他方法来达到维生素D充足。
Inadequate sun exposure and dietary vitamin D intake can result in vitamin D insufficiency. However, limited data are available on actual vitamin D status and predictors in healthy individuals in different regions and by season. We compared vitamin D status [25-hydroxyvitamin D; 25(OH)D] in people < 60 years of age using data from cross-sectional studies of three regions across Australia: southeast Queensland (27°S; 167 females and 211 males), Geelong region (38°S; 561 females), and Tasmania (43°S; 432 females and 298 males). The prevalence of vitamin D insufficiency (≤ 50 nmol/L) in women in winter/spring was 40.5% in southeast Queensland, 37.4% in the Geelong region, and 67.3% in Tasmania. Season, simulated maximum daily duration of vitamin D synthesis, and vitamin D effective daily dose each explained around 14% of the variation in 25(OH)D. Although latitude explained only 3.9% of the variation, a decrease in average 25(OH)D of 1.0 (95% confidence interval, 0.7–1.3) nmol/L for every degree increase in latitude may be clinically relevant. In some months, we found a high insufficiency or even deficiency when sun exposure protection would be recommended on the basis of the simulated ultraviolet index. Vitamin D insufficiency is common over a wide latitude range in Australia. Season appears to be more important than latitude, but both accounted for less than one-fifth of the variation in serum 25(OH)D levels, highlighting the importance of behavioral factors. Current sun exposure guidelines do not seem to fully prevent vitamin D insufficiency, and consideration should be given to their modification or to pursuing other means to achieve vitamin D adequacy.
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影响因子：
2.5
作者：
Henry, MJ;Pasco, JA;Kotowicz, MA
通讯作者：
Kotowicz, MA
影响因子：
7.1
作者：
HOLICK, MF
通讯作者：
HOLICK, MF
影响因子：
--
作者：
McGrath, J;El-Saadi, O;Mowry, B
通讯作者：
Mowry, B
影响因子：
4.7
作者：
Oliveri, B;Plantalech, L;Mautalen, CA
通讯作者：
Mautalen, CA
影响因子：
4
作者：
Lucas, JA;Bolland, MJ;Reid, IR
通讯作者：
Reid, IR