Altered Reward Processing and Sex Differences in Chronic Pain.
Altered Reward Processing and Sex Differences in Chronic Pain.
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慢性疼痛中改变的奖赏加工和性别差异
DOI：
10.3389/fnins.2022.889849
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发表时间：
2022
影响因子：
4.3
通讯作者：
Love, Tiffany M.
中科院分区：
文献类型：
--
作者：
Baker, Anne K.;Ericksen, Lauren C.;Koppelmans, Vincent;Mickey, Brian J.;Martucci, Katherine T.;Zubieta, Jon-Kar;Love, Tiffany M.
慢性疼痛和奖励处理被认为是相互关联的。先前对慢性疼痛患者的奖励处理的研究报告了不一致的结果。虽然有几个因素可能导致这些不同的结果，但之前的这些研究并没有按性别对分析进行分层——之前的研究表明，这一因素会强烈影响与奖励相关的反应。因此，我们在慢性非特异性背痛患者和健康对照（HC）患者中，在预期金钱激励期间，将性别作为纹状体激活水平的一个重要因素进行了研究。这项研究在金钱激励延迟任务中利用功能磁共振成像来评估患有或不患有慢性疼痛的男性和女性纹状体的奖励和损失反应性（N = 90）。通过重复测量方差分析来分析群体、性别和不同性别之间的相互作用。在 HC 中，男性在奖励预期期间，特别是在大型奖励试验期间，纹状体中表现出明显更高的血氧水平依赖性（BOLD）信号。相比之下，患者之间没有观察到显着的性别差异。还观察到了显着的性别间相互作用，表明与对照男性相比，患有慢性疼痛的男性的 BOLD 反应减弱。这些结果提供了新的证据，证明慢性疼痛患者对奖励的预期反应因性别而减少。男性纹状体奖赏反应性的改变，而非女性，表明男性和女性的奖赏系统特别受到慢性疼痛的干扰，并强调了将性别作为未来持续性疼痛背景下奖赏反应性研究的一个感兴趣因素的价值。
Chronic pain and reward processing are understood to be reciprocally related to one another. Previous studies of reward processing in chronic pain patients have reported incongruent findings. While several factors likely contribute to these disparate findings, these previous studies did not stratify their analyses by sex—a factor previously shown to robustly impact reward-related responses. Thus, we examined sex as a factor of interest in level of striatal activation during anticipation of monetary incentives among patients with chronic non-specific back pain and healthy controls (HC). This study utilized functional magnetic resonance imaging during a monetary incentive delay task to evaluate reward and loss responsivity in the striatum among males and females with and without chronic pain (N = 90). Group, sex, and group-by-sex interactions were analyzed via repeated measures analysis of variance. Among HC, males exhibited significantly greater blood oxygen level dependent (BOLD) signal in the striatum during reward anticipation, particularly during large reward trials. By contrast, no significant sex differences were observed among patients. A significant group-by-sex interaction was also observed, revealing diminished BOLD responses among males with chronic pain relative to control males. These results provide novel evidence of sex-specific reductions in anticipatory responses to reward in patients with chronic pain. Altered striatal reward responsivity among males, but not females, suggests that the reward systems of males and females are uniquely disrupted by chronic pain, and highlights the value of including sex as a factor of interest in future studies of reward responsivity in the context of persistent pain.
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影响因子：
16.2
作者：
Baliki, Marwan N.;Geha, Paul Y.;Fields, Howard L.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
影响因子：
5.3
作者：
Martikainen, Ilkka K.;Pecina, Marta;Zubieta, Jon-Kar
通讯作者：
Zubieta, Jon-Kar
影响因子：
5.7
作者：
Kim, Minhae;Mawla, Ishtiaq;Loggia, Marco L.
通讯作者：
Loggia, Marco L.
影响因子：
5.3
作者：
Cosgrove, Kelly P.;Wang, Shuo;Morris, Evan D.
通讯作者：
Morris, Evan D.
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.