Personalized four-category staging for predicting prognosis in patients with small bowel Adenocarcinoma: an international development and validation study.
Personalized four-category staging for predicting prognosis in patients with small bowel Adenocarcinoma: an international development and validation study.
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预测小肠腺癌患者预后的个性化四类分期：一项国际开发和验证研究
DOI：
10.1016/j.ebiom.2020.102979
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发表时间：
2020-10
期刊：
影响因子：
11.1
通讯作者：
Ge ZZ
中科院分区：
文献类型：
--
作者：
Dai ZH;Wang QW;Zhang QW;Yan XL;Aparicio T;Zhou YY;Wang H;Zhang CH;Zaanan A;Afchain P;Zhang Y;Chen HM;Gao YJ;Ge ZZ
阳性淋巴结的对数优势比(LODDS)在预测小肠腺癌(SBA)患者的生存方面优于第8版N分期。本研究的目的是建立和验证SBA的肿瘤、LODDS和转移(TLM)分期。1988年至2010年监测、流行病学和最终结果(SEER)数据库中的1789名SBA患者，2011-2013年SEER数据库中的437名患者和来自多个中心的166名患者分别被归类为开发、验证和测试队列。TLM分期是在开发队列中使用癌症数据聚集集成算法(EACCD)方法开发的。C-index用于评估TLM分期在预测肿瘤特异性生存(CSS)方面的表现，并与传统的第8版TNM分期进行比较。为发展队列设计的四类TLM分期在预测发展队列(0.682比0.650，P=0.001)、验证队列(0.682比0.654，P=0.022)和测试队列(0.659比0.611，P=0.023)的条件随机性方面显示出更高的区分力。在TNM分期II/III期或淋巴结转移<8的患者中，TLM分期的预测效能仍高于第8期TNM分期。TLM分期对SBA患者的预后判断优于第8期TNM分期，尤其是对II/III期或淋巴结转移<8的患者，因此，TLM分期可作为对TNM分期的补充。为这项研究作出贡献的资助机构的完整名单可在确认部分找到。
Log odds of positive lymph nodes (LODDS) classification showed superiority over 8th edition N staging in predicting survival of small bowel adenocarcinoma (SBA) patients. The aim of this study was to develop and validate the Tumor, LODDS, and Metastasis (TLM) staging of SBA. Totally 1789 SBA patients from the Surveillance, Epidemiology, and End Results (SEER) database between 1988–2010, 437 patients from SEER database between 2011–2013 and 166 patients from multicenters were categorized into development, validation and test cohort, respectively. The TLM staging was developed in the development cohort using Ensemble Algorithm for Clustering Cancer Data (EACCD) method. C-index was used to assess the performance of the TLM staging in predicting cancer-specific survival (CSS) and was compared with the traditional 8th edition TNM staging. Four-category TLM staging designed for the development cohort showed higher discriminatory power than TNM staging in predicting CSS in the development cohort (0.682 vs. 0.650, P < 0.001), validation cohort (0.682 vs. 0.654, P = 0.022), and test cohort (0.659 vs. 0.611, P = 0.023), respectively. TLM staging continued to show its higher predictive efficacy than the 8th TNM in TNM stage II/III patients or in patients with lymph node yield less than 8. TLM staging showed a better prognostic performance than the 8th TNM staging especially TNM stage II/III or patients with lymph node yield less than 8 and therefore, could serve to complement the TNM staging in patients with SBA. A full list of funding bodies that contributed to this study can be found in the Acknowledgements section.
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影响因子：
2.6
作者：
Wu, TJ;Yeh, CN;Chen, MF
通讯作者：
Chen, MF
影响因子：
3.7
作者：
Overman MJ;Hu CY;Kopetz S;Abbruzzese JL;Wolff RA;Chang GJ
通讯作者：
Chang GJ
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Ward, Elizabeth
通讯作者：
Ward, Elizabeth
影响因子：
3.3
作者：
Horimatsu T;Nakayama N;Moriwaki T;Hirashima Y;Fujita M;Asayama M;Moriyama I;Nakashima K;Baba E;Kitamura H;Tamura T;Hosokawa A;Yoshimura K;Muto M
通讯作者：
Muto M
影响因子：
2
作者：
Kang, Le;Chen, Weijie;Petrick, Nicholas A.;Gallas, Brandon D.
通讯作者：
Gallas, Brandon D.