The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics.
The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics.
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小鼠遗传资源的多态性结构使用全基因组重新陈述数据阐明：对QTL发现和系统遗传学的影响。
DOI：
10.1007/s00335-007-9045-1
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发表时间：
2007-07
期刊：
影响因子：
2.5
通讯作者：
Threadgill, David W.
中科院分区：
文献类型：
--
作者：
Roberts, Adam;Pardo-Manuel de Villena, Fernando;Wang, Wei;McMillan, Leonard;Threadgill, David W.
小鼠遗传资源包括近交系、重组近交系、染色体置换系、异质原种和协作杂交（CC）。这些资源是通过各种育种设计产生的，这些育种设计可能产生不同的遗传结构，包括所代表的多样性水平、变异的空间分布和资源内的等位基因频率。通过结合16个近交系的测序数据和相关品系的记录历史，确定了小鼠资源中遗传变异的结构。小家鼠的遗传多样性分布不均匀，最常用的资源只有小家鼠遗传多样性的一小部分，从而导致许多盲点。仅包括来自M以外亚种的野生衍生近交系的资源。M.无盲点和均匀分布的变异。与其他主要适用于基因发现的资源不同，CC是唯一可以支持全基因组网络分析的资源，这是系统遗传学的基础。CC捕获了更多的遗传多样性，没有盲点，并且比所有其他资源具有更均匀的变异分布。此外，CC中等位基因频率的分布类似于在自然群体如人类中所见的分布，其中许多变体以低频率发现，并且只有少数变体是常见的。我们的结论是，CC代表了一个显着的改善现有的遗传资源的哺乳动物系统生物学应用。
Mouse genetic resources include inbred strains, recombinant inbred lines, chromosome substitution strains, heterogeneous stocks, and the Collaborative Cross (CC). These resources were generated through various breeding designs that potentially produce different genetic architectures, including the level of diversity represented, the spatial distribution of the variation, and the allele frequencies within the resource. By combining sequencing data for 16 inbred strains and the recorded history of related strains, the architecture of genetic variation in mouse resources was determined. The most commonly used resources harbor only a fraction of the genetic diversity of Mus musculus, which is not uniformly distributed thus resulting in many blind spots. Only resources that include wild-derived inbred strains from subspecies other than M. m. domesticus have no blind spots and a uniform distribution of the variation. Unlike other resources that are primarily suited for gene discovery, the CC is the only resource that can support genome-wide network analysis, which is the foundation of systems genetics. The CC captures significantly more genetic diversity with no blind spots and has a more uniform distribution of the variation than all other resources. Furthermore, the distribution of allele frequencies in the CC resembles that seen in natural populations like humans in which many variants are found at low frequencies and only a minority of variants are common. We conclude that the CC represents a dramatic improvement over existing genetic resources for mammalian systems biology applications.
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影响因子：
9.8
作者：
Pletcher MT;McClurg P;Batalov S;Su AI;Barnes SW;Lagler E;Korstanje R;Wang X;Nusskern D;Bogue MA;Mural RJ;Paigen B;Wiltshire T
通讯作者：
Wiltshire T
影响因子：
1.5
作者：
Bogue, MA;Grubb, SC
通讯作者：
Grubb, SC
影响因子：
3.2
作者：
DEMANT, P;HART, AAM
通讯作者：
HART, AAM
影响因子：
7
作者：
Ideraabdullah, FY;de la Casa-Esperón, E;de Villena, FPM
通讯作者：
de Villena, FPM
影响因子：
6.2
作者：
BAILEY, DW
通讯作者：
BAILEY, DW