The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.
The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.
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DOI：
10.1371/journal.pcbi.1000431
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发表时间：
2009-07
影响因子：
4.3
通讯作者：
Reference Genome Group of the Gene Ontology Consortium
中科院分区：
文献类型：
--
作者：
Reference Genome Group of the Gene Ontology Consortium
基因本体论（GO）是一项协作努力，提供结构化的词汇，以注释基因产物的分子功能，生物学作用和细胞位置，以高度系统的方式和物种中性的方式，目的是统一基因表示。跨不同生物的功能。 GO财团的每个贡献成员都独立将其注释的生物体与基因产品相关。在这里，我们介绍了参考基因组项目，该项目将这些独立的努力汇总到基于这些不同生物体基因之间的进化关系的统一框架中。参考基因组项目有两个主要目标：提高项目中每个生物体中基因的深度和广度，并创建数据集和工具，以使其他基因组注释努力在其其同源基因中推断出其同源基因的注释。有机体。此外，该项目具有几个重要的偶然益处，例如增加了基因组数据库的注释一致性，并为GO的逻辑结构和生物含量提供了重要的改进。
生物学研究越来越多地取决于生物数据结构良好的表示的可用性，并提供了数据存储库策展人提供的详细，准确的描述。参考基因组项目的目标是为人类以及11种生物研究中的重要模型提供全面的功能注释。为了实现这一目标，我们开发了一种方法，该方法将基于实验的注释超过系统发育树的叶子，然后手动注释共同祖先的功能，这是基于以下假设，即祖先具有共同确定的共同实验性功能在这些叶子上，这些功能在每个家庭的所有其他后代中都可能是保守的。
The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a species-neutral manner with the aim of unifying the representation of gene function across different organisms. Each contributing member of the GO Consortium independently associates GO terms to gene products from the organism(s) they are annotating. Here we introduce the Reference Genome project, which brings together those independent efforts into a unified framework based on the evolutionary relationships between genes in these different organisms. The Reference Genome project has two primary goals: to increase the depth and breadth of annotations for genes in each of the organisms in the project, and to create data sets and tools that enable other genome annotation efforts to infer GO annotations for homologous genes in their organisms. In addition, the project has several important incidental benefits, such as increasing annotation consistency across genome databases, and providing important improvements to the GO's logical structure and biological content. Biological research is increasingly dependent on the availability of well-structured representations of biological data with detailed, accurate descriptions provided by the curators of the data repositories. The Reference Genome project's goal is to provide comprehensive functional annotation for the genomes of human as well as eleven organisms that are important models in biomedical research. To achieve this, we have developed an approach that superposes experimentally-based annotations onto the leaves of phylogenetic trees and then we manually annotate the function of the common ancestors, predicated on the assumption that the ancestors possessed the experimentally determined functions that are held in common at these leaves, and that these functions are likely to be conserved in all other descendents of each family.
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非par体6：具有内核的真核直系同源群。
影响因子：
14.9
作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
Bioinformatics (Oxford, England)
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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