Heritability of the Human Craniofacial Complex.
Heritability of the Human Craniofacial Complex.
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DOI：
10.1002/ar.23186
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Sherwood RJ
中科院分区：
文献类型：
--
作者：
Šešelj M;Duren DL;Sherwood RJ
量化解剖结构的正常变异和遗传基础是现代形态学研究的主要目标之一。然而，遗传对人类颅面形态正常变异的贡献程度仍不清楚。目前的研究通过调查正常颅面形态的遗传基础来解决这一差距。正在研究的样本由跨越整个颅面复合体的 75 个线性和角度测量值组成，记录自 Fels 纵向研究中 1,379 名参与者的侧位头颅照片。使用 SOLAR 估计每个性状的遗传力，SOLAR 是一种利用所有谱系信息进行参数估计的最大似然方差分量方法。在分析模型中同时估计了协变量年龄、性别、年龄2、性别×年龄和性别×年龄2的特征均值和平均效应。颅面复合体的所有特征均具有显着的遗传性。遗传力估计范围为 0.10 至 0.60，大多数为中等遗传力。值得注意的是，我们发现颅面复合体、内脏颅骨、基底颅骨和神经颅骨的不同功能/发育组成部分存在相似的遗传力范围。这表明颅面复合体不同区域的特征对于种群历史和系统发育重建的目的具有相当的效用。与此同时，这种遗传对颅面形态的影响提醒非遗传研究的研究人员在考虑其项目设计和目标选择研究样本时考虑这一发现的影响。
Quantifying normal variation and the genetic underpinnings of anatomical structures is one of the main goals of modern morphological studies. However, the extent of genetic contributions to normal variation in craniofacial morphology in humans is still unclear. The current study addresses this gap by investigating the genetic underpinnings of normal craniofacial morphology The sample under investigation consists of 75 linear and angular measurements spanning the entire craniofacial complex, recorded from lateral cephalographs of 1,379 participants in the Fels Longitudinal Study. Heritabilities for each trait were estimated using SOLAR, a maximum-likelihood variance components approach utilizing all pedigree information for parameter estimation. Trait means and mean effects of the covariates age, sex, age2, sex × age, and sex × age2 were simultaneously estimated in the analytic models. All traits of the craniofacial complex were significantly heritable. Heritability estimates ranged from 0.10 to 0.60, with the majority being moderate. It is important to note that we found similar ranges of heritability occurring across the different functional/developmental components of the craniofacial complex, the splanchnocranium, the basicranium, and the neurocranium. This suggests that traits from different regions of the craniofacial complex are of comparable utility for the purposes of population history and phylogeny reconstruction. At the same time, this genetic influence on craniofacial morphology signals a caution to researchers of nongenetic studies to consider the implications of this finding when selecting samples for study given their project design and goals.
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影响因子：
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