Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis.

Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis.
复制标题

DOI:
10.1007/s00018-012-1177-0
复制
发表时间:
2013-07
影响因子:
8
通讯作者:
Altieri, Dario C.
Altieri, Dario C.
中科院分区:
生物学1区
文献类型:
--
作者:
Altieri, Dario C.

文献摘要

参考文献

被引文献

相似文献

尽管线粒体对能量产生和细胞命运的决定至关重要,但线粒体中控制蛋白质稳态的机制直到最近才开始出现。新的实验证据揭示了热休克蛋白90 (Hsp90)家族的分子伴侣在监督线粒体中蛋白质折叠环境中的作用。最初与防止细胞死亡有关,现在有证据表明,线粒体中以hsp90为导向的蛋白质质量控制与细胞稳态网络宿主有关,而细胞稳态网络在人类癌症中被显著利用。
Although essential for energy production and cell fate decisions, the mechanisms that govern protein homeostasis, or proteostasis, in mitochondria are only recently beginning to emerge. Fresh experimental evidence has uncovered a role of molecular chaperones of the Heat Shock Protein-90 (Hsp90) family in overseeing the protein folding environment in mitochondria. Initially implicated in protection against cell death, there is now evidence that Hsp90-directed protein quality control in mitochondria connects to hosts of cellular homeostastic networks that become prominently exploited in human cancer.
DOI: 10.1016/j.ccr.2012.07.015
发表时间: 2012-09-11
期刊: Cancer cell
影响因子: 50.3
作者:
Chae YC;Caino MC;Lisanti S;Ghosh JC;Dohi T;Danial NN;Villanueva J;Ferrero S;Vaira V;Santambrogio L;Bosari S;Languino LR;Herlyn M;Altieri DC
通讯作者: Altieri DC
DOI: 10.1016/j.biocel.2009.04.010
发表时间: 2009-10
影响因子: 4
作者:
Giorgi, Carlotta;De Stefani, Diego;Bononi, Angela;Rizzuto, Rosario;Pinton, Paolo
通讯作者: Pinton, Paolo
DOI: 10.1093/emboj/18.3.522
发表时间: 1999-02-01
期刊: EMBO JOURNAL
影响因子: 11.4
作者:
Biswas, G;Adebanjo, OA;Avadhani, NG
通讯作者: Avadhani, NG
DOI: 10.1080/10253890701314863
发表时间: 2007-11-01
影响因子: 2.3
作者:
Gesualdi, N. Montesano;Chirico, G.;Esposito, F.
通讯作者: Esposito, F.
DOI: 10.1242/jcs.075119
发表时间: 2010-11-15
影响因子: 4
作者:
Haynes, Cole M.;Ron, David
通讯作者: Ron, David