Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis.
Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis.
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DOI:
10.1007/s00018-012-1177-0
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发表时间:
2013-07
影响因子:
8
通讯作者:
Altieri, Dario C.
中科院分区:
文献类型:
--
作者:
Altieri, Dario C.
Although essential for energy production and cell fate decisions, the mechanisms that govern protein homeostasis, or proteostasis, in mitochondria are only recently beginning to emerge. Fresh experimental evidence has uncovered a role of molecular chaperones of the Heat Shock Protein-90 (Hsp90) family in overseeing the protein folding environment in mitochondria. Initially implicated in protection against cell death, there is now evidence that Hsp90-directed protein quality control in mitochondria connects to hosts of cellular homeostastic networks that become prominently exploited in human cancer.
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