IL-35, as a newly proposed homeostasis-associated molecular pattern, plays three major functions including anti-inflammatory initiator, effector, and blocker in cardiovascular diseases.
IL-35, as a newly proposed homeostasis-associated molecular pattern, plays three major functions including anti-inflammatory initiator, effector, and blocker in cardiovascular diseases.
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DOI：
10.1016/j.cyto.2017.06.003
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发表时间：
2019-10
期刊：
影响因子：
3.8
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Li X;Fang P;Yang WY;Wang H;Yang X
IL-35是2007年发现的一种新型抗炎细胞因子，它通过诱导调节性T细胞和调节性B细胞并抑制效应T细胞和巨噬细胞来抑制炎症和免疫反应。 IL-35 独特的引发剂和效应剂抗炎特性引起了人们对研究其在心血管疾病 (CVD) 发展过程中的作用的极大兴趣，其中炎症过程被牢固地确定为其发展和并发症的核心。在这篇综述中，我们更新了对细胞中 IL-35 如何产生和调节的最新理解。此外，我们概述了不同细胞类型中受 IL-35 影响的信号通路。此外，我们总结了 IL-35 在动脉粥样硬化、糖尿病和脓毒症中的作用。我们提出了一个新的工作模型，即 IL-35 及其受体分别是新型稳态相关分子模式 (HAMP) 和 HAMP 受体，这解释了 IL-35 信号传导作为抗炎启动子、效应子和阻滞剂的复杂性质。深入了解这一主题对于开发针对心血管疾病和其他疾病的新抗炎疗法具有重要意义。
IL-35 is a new anti-inflammatory cytokine identified in 2007, which inhibits inflammation and immune responses by inducing regulatory T cells and regulatory B cells and suppressing effector T cells and macrophages. The unique initiator and effector anti-inflammatory properties of IL-35 bring tremendous interest in investigating its role during cardiovascular disease (CVD) development, in which inflammatory processes are firmly established as central to its development and complications. In this review, we update recent understanding of how IL-35 is produced and regulated in the cells. In addition, we outline the signaling pathways affected by IL-35 in different cell types. Furthermore, we summarize the roles of IL-35 in atherosclerosis, diabetes, and sepsis. We propose a new working model that IL-35 and its receptors are novel homeostasis-associated molecular pattern (HAMP) and HAMP receptors, respectively, which explains the complex nature of IL-35 signaling as an anti-inflammatory initiator, effector and blocker. Thorough understanding of this topic is significant towards development of new anti-inflammatory therapies against CVDs and other diseases.
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血浆 IL-35 水平降低与冠状动脉疾病中的左心室射血分数相关
影响因子：
3.7
作者：
Lin Y;Huang Y;Lu Z;Luo C;shi Y;Zeng Q;Cao Y;Liu L;Wang X;Ji Q
通讯作者：
Ji Q
影响因子：
5.4
作者：
Manzoor F;Johnson MC;Li C;Samulski RJ;Wang B;Tisch R
通讯作者：
Tisch R
DOI：
10.1073/pnas.94.22.12041
发表时间：
1997-10-28
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
20.1
作者：
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通讯作者：
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影响因子：
4.8
作者：
Chehboun, Salma;Labrecque-Carbonneau, Jeremie;Gauchat, Jean-Francois
通讯作者：
Gauchat, Jean-Francois