Decreased plasma IL-35 levels are related to the left ventricular ejection fraction in coronary artery diseases.
Decreased plasma IL-35 levels are related to the left ventricular ejection fraction in coronary artery diseases.
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血浆 IL-35 水平降低与冠状动脉疾病中的左心室射血分数相关
DOI：
10.1371/journal.pone.0052490
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Ji Q
中科院分区：
文献类型：
--
作者：
Lin Y;Huang Y;Lu Z;Luo C;shi Y;Zeng Q;Cao Y;Liu L;Wang X;Ji Q
背景越来越多的证据表明，新型抗炎细胞因子IL-35能有效抑制效应T细胞活性，改变炎症和自身免疫性疾病的进展。IL-35的两个亚基EBI 3和p35在人类晚期斑块中强烈表达，提示IL-35在动脉粥样硬化和冠状动脉疾病（CAD）中的潜在作用。然而，IL-35在CAD患者的血浆水平还有待研究。方法采用酶联免疫吸附试验（ELISA）检测43例稳定型心绞痛（SAP）、62例不稳定型心绞痛（UAP）、56例急性心肌梗死（AMI）患者和47例胸痛综合征患者血浆IL-35、IL-10、TGF-β1、IL-12和IL-27水平。结果SAP组、UAP组和AMI组血浆IL-35水平分别为90.74±34.22 pg/ml、72.20±26.63 pg/ml和50.21±24.69 pg/ml，与胸痛综合征组（115.06±32.27 pg/ml）比较，差异有显著性（P <0.05）。用IL-10和TGF-β1也证明了类似的结果。不稳定型心绞痛患者血浆IL-12和IL-27水平明显升高（349.72±85.22 pg/ml，101.75±51.42 pg/ml）与AMI组比较，P <0.01（318.05±86.82 pg/ml，148.88±68.45 pg/ml）与胸痛证组比较SAP组分别为153.84±53.86 pg/ml、70.84±38.77 pg/ml。此外，较低的IL-35水平与CAD患者的左心室射血分数（LVEF）呈中度正相关（R = 0.416，P<0.01），而较高的IL-27水平与CAD患者的LVEF呈弱负相关（R =-0.205，P<0.01）。 结论本研究结果表明，循环IL-35是一种潜在的新的冠状动脉疾病的生物标志物。调节IL-35的表达也为动脉粥样硬化和CAD的治疗提供了一个新的可能的靶点。
Background Accumulating evidence shows that the novel anti-inflammatory cytokine IL-35 can efficiently suppress effector T cell activity and alter the progression of inflammatory and autoimmune diseases. The two subunits of IL-35, EBI3 and p35, are strongly expressed in human advanced plaque, suggesting a potential role of IL-35 in atherosclerosis and coronary artery disease (CAD). However, the plasma levels of IL-35 in patients with CAD have yet to be investigated. Methods Plasma IL-35, IL-10, TGF-β1, IL-12 and IL-27 levels were measured using an ELISA in 43 stable angina pectoris (SAP) patients, 62 unstable angina pectoris (UAP) patients, 56 acute myocardial infarction (AMI) patients and 47 chest pain syndrome patients as a control group. Results The results showed that plasma IL-35 levels were significantly decreased in the SAP group (90.74±34.22 pg/ml), the UAP group (72.20±26.63 pg/ml), and the AMI group (50.21±24.69 pg/ml) compared with chest pain syndrome group (115.06±32.27 pg/ml). Similar results were also demonstrated with IL-10 and TGF-β1. Plasma IL-12 and IL-27 levels were significantly increased in the UAP group (349.72±85.22 pg/ml, 101.75±51.42 pg/ml, respectively) and the AMI group (318.05±86.82 pg/ml, 148.88±68.45 pg/ml, respectively) compared with chest pain syndrome group (138.68±34.37 pg/ml, 63.60±22.75 pg/ml, respectively) and the SAP group (153.84±53.86 pg/ml, 70.84±38.77 pg/ml, respectively). Furthermore, lower IL-35 levels were moderately positively correlated with left ventricular ejection fraction (LVEF) in CAD patients (R = 0.416, P<0.01), whereas higher IL-27 levels were weakly negatively correlated with LVEF in CAD patients(R = −0.205, P<0.01). Conclusions The results of the present study show that circulating IL-35 is a potentially novel biomarker for coronary artery disease. Regulating the expression of IL-35 also provides a new possible target for the treatment of atherosclerosis and CAD.
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DOI：
10.1073/pnas.94.22.12041
发表时间：
1997-10-28
影响因子：
11.1
作者：
Devergne, O;Birkenbach, M;Kieff, E
通讯作者：
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影响因子：
5.7
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Kilic, T.;Ural, D.;Komsuoglu, B.
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Komsuoglu, B.
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4.4
作者：
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Chua, Kaw Yan
DOI：
10.4049/jimmunol.1100315
发表时间：
2011-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Chaturvedi V;Collison LW;Guy CS;Workman CJ;Vignali DA
通讯作者：
Vignali DA
DOI：
10.4049/jimmunol.0803646
发表时间：
2009-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Collison LW;Pillai MR;Chaturvedi V;Vignali DA
通讯作者：
Vignali DA