Autoantibodies against a 43 KDa muscle protein in inclusion body myositis.
Autoantibodies against a 43 KDa muscle protein in inclusion body myositis.
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DOI：
10.1371/journal.pone.0020266
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Greenberg SA
中科院分区：
文献类型：
--
作者：
Salajegheh M;Lam T;Greenberg SA
Inclusion body myositis (IBM) is a poorly understood and refractory autoimmune muscle disease. Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease. Plasma autoantibodies from 65 people, including 25 with IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%) IBM patient samples recognized an approximately 43 kDa muscle protein. No other disease (N = 25) or healthy volunteer (N = 15) samples recognized this protein. Circulating antibodies against a 43-kDa muscle autoantigen may lead to the discovery of a novel biomarker for IBM. Its high specificity for IBM among patients with autoimmune myopathies furthermore suggests a relationship to disease pathogenesis.
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