Diabetes and cardiovascular disease: the potential benefit of incretin-based therapies.
Diabetes and cardiovascular disease: the potential benefit of incretin-based therapies.
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DOI：
10.1007/s11883-010-0153-0
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发表时间：
2011-04
影响因子：
5.8
通讯作者：
Aguilar, David
中科院分区：
文献类型：
--
作者：
Addison, Daniel;Aguilar, David
2型糖尿病的健康负担在全球范围内持续增加。这种负担的很大一部分是由于糖尿病患者心血管疾病的发展。最近强化血糖控制以减少大血管事件的临床试验失败，加上某些糖尿病治疗的潜在危害报告，导致随着新的糖尿病治疗方法的开发而增加审查。肠促胰岛素肽是一组通过多种机制调节葡萄糖代谢的胃肠道蛋白质，并且已经开发了基于肠促胰岛素的疗法来治疗2型糖尿病。这些药物包括胰高血糖素样肽-1（GLP-1）和二肽基肽酶-IV（DPP-IV）抑制剂。除了对葡萄糖稳态的影响外，越来越多的证据表明这些肽也可能影响心血管系统。在这篇综述中，我们讨论了最近的研究结果的潜在的，但未经测试的，在治疗心血管疾病的肠促胰岛素为基础的药物治疗的好处。
The health burden of type 2 diabetes mellitus continues to increase worldwide. A substantial portion of this burden is due to the development of cardiovascular disease in patients with diabetes. Recent failures of clinical trials of intensive glucose control to reduce macrovascular events, coupled with reports of potential harm of certain diabetic therapy, have led to increased scrutiny as new diabetic therapies are developed. Incretin peptides are a group of gastrointestinal proteins that regulate glucose metabolism through multiple mechanisms, and incretin-based therapies have been developed to treat type 2 diabetes. These agents include glucagon-like peptide-1 (GLP-1) and dipeptidyl peptidase-IV (DPP-IV) inhibitors. In addition to effects on glucose homeostasis, growing evidence suggest that these peptides may also affect the cardiovascular system. In this review, we discuss recent findings concerning the potential, yet untested, benefits of incretin-based pharmacotherapy in the treatment of cardiovascular disease.
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影响因子：
120.7
作者：
Narayan, KMV;Boyle, JP;Williamson, DF
通讯作者：
Williamson, DF
DOI：
10.1161/circheartfailure.109.900282
发表时间：
2010-07
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Bhashyam S;Fields AV;Patterson B;Testani JM;Chen L;Shen YT;Shannon RP
通讯作者：
Shannon RP
影响因子：
16.2
作者：
Laakso M
通讯作者：
Laakso M
影响因子：
5.3
作者：
Fadini, Gian Paolo;de Kreutzenberg, Saula;Avogaro, Angelo
通讯作者：
Avogaro, Angelo
影响因子：
4.8
作者：
Gros, R;You, XM;Husain, M
通讯作者：
Husain, M