Metabolic reprogramming: A driver of cigarette smoke-induced inflammatory lung diseases.
Metabolic reprogramming: A driver of cigarette smoke-induced inflammatory lung diseases.
复制标题
代谢重编程：香烟烟雾引起的炎症性肺部疾病的驱动因素。
DOI：
10.1016/j.freeradbiomed.2020.12.438
复制
发表时间：
2021-02-01
影响因子：
7.4
通讯作者：
Chen CH
中科院分区：
文献类型：
--
作者：
Li L;Yang DC;Chen CH
吸烟是众所周知的肺部疾病的危险因素，包括慢性阻塞性肺疾病（COPD）、哮喘和肺纤维化。尽管在剖析与疾病发展和进展相关的机制方面取得了重大进展，但这些发现仅代表了多方面疾病的一个方面。这种方法的一个关键后果是，许多治疗性治疗往往无法改善或逆转疾病状态，因为其他条件和变量没有得到充分考虑。为了扩大我们对肺部疾病的理解，组学方法，特别是代谢组学，已经在该领域出现。这种策略已被应用于识别推定的生物标志物和新的机制见解。在这篇综述中，我们讨论了COPD、哮喘和特发性肺纤维化（IPF）患者的代谢特征，重点关注吸烟改变代谢调节的直接影响。接下来，我们将介绍基于细胞和动物的实验，并指出靶向代谢重编程在炎症性肺病中的治疗潜力。此外，还讨论了将这些发现转化为临床实践的障碍，包括潜在的不良反应和有限的药理学疗效。
Cigarette smoking is a well-known risk factor for pulmonary diseases, including chronic obstructive pulmonary disease (COPD), asthma and pulmonary fibrosis. Despite major progress in dissecting the mechanisms associated with disease development and progression, findings only represent one aspect of multifaceted disease. A crucial consequence of this approach is that many therapeutic treatments often fail to improve or reverse the disease state as other conditions and variables are insufficiently considered. To expand our understanding of pulmonary diseases, omics approaches, particularly metabolomics, has been emerging in the field. This strategy has been applied to identify putative biomarkers and novel mechanistic insights. In this review, we discuss metabolic profiles of patients with COPD, asthma, and idiopathic pulmonary fibrosis (IPF) with a focus on the direct effects of cigarette smoking in altering metabolic regulation. We next present cell- and animal-based experiments and point out the therapeutic potential of targeting metabolic reprogramming in inflammatory lung diseases. In addition, the obstacles in translating these findings into clinical practice, including potential adverse effects and limited pharmacological efficacy, are also addressed.
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影响因子：
82.9
作者：
Cloonan SM;Glass K;Laucho-Contreras ME;Bhashyam AR;Cervo M;Pabón MA;Konrad C;Polverino F;Siempos II;Perez E;Mizumura K;Ghosh MC;Parameswaran H;Williams NC;Rooney KT;Chen ZH;Goldklang MP;Yuan GC;Moore SC;Demeo DL;Rouault TA;D'Armiento JM;Schon EA;Manfredi G;Quackenbush J;Mahmood A;Silverman EK;Owen CA;Choi AM
通讯作者：
Choi AM
DOI：
10.1152/ajplung.00219.2012
发表时间：
2012-11-01
影响因子：
4.9
作者：
Agarwal, Amit R.;Zhao, Liqin;Cadenas, Enrique
通讯作者：
Cadenas, Enrique
DOI：
10.1186/s40413-018-0192-5
发表时间：
2018
期刊：
The World Allergy Organization journal
影响因子：
--
作者：
Caminati M;Pham DL;Bagnasco D;Canonica GW
通讯作者：
Canonica GW
DOI：
10.1152/ajplung.00155.2013
发表时间：
2014-05-01
影响因子：
4.9
作者：
Aravamudan, Bharathi;Kiel, Alexander;Prakash, Y. S.
通讯作者：
Prakash, Y. S.
DOI：
10.1164/rccm.201204-0754oc
发表时间：
2012-11-01
影响因子：
24.7
作者：
Booth, Adam J.;Hadley, Ryan;White, Eric S.
通讯作者：
White, Eric S.