Type 2 immunity in asthma.
Type 2 immunity in asthma.
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DOI：
10.1186/s40413-018-0192-5
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Canonica GW
中科院分区：
文献类型：
--
作者：
Caminati M;Pham DL;Bagnasco D;Canonica GW
2型免疫代表了特应性个体对过敏原暴露的典型适应性反应。它主要涉及Th2细胞和免疫球蛋白E，它们是2型炎症的主要协调者。最近，人们强调，除了特异性IgE激活外，过敏原可能是Th2反应的原因，许多其他环境刺激，如病毒和污染物，可以引发除特应性外的相同炎症模式。从解剖学和功能的角度来看，新出现的数据支持所谓的上皮功能障碍在哮喘发病机制中的重要作用。此外，越来越多的证据表明先天免疫与哮喘患者Th2受损反应极化的相关性。从这个角度来看，气道上皮、先天免疫和适应性免疫之间复杂的交叉对话正在成为除过敏原外2型炎症的主要决定因素。这篇综述将包括先天性和适应性2型免疫失调在哮喘发病机制中的相关性的最新进展，特别是严重哮喘，以及与严重哮喘相关的过敏原的作用。2型免疫也将根据目前和即将到来的针对严重哮喘的靶向治疗进行审查。
Type 2-immunity represents the typical adaptive response to allergen exposure in atopic individuals. It mainly involves Th2 cells and immunoglobulin E, as the main orchestrators of type 2-inflammation. Recently, it has been highlighted that allergens may be responsible for a Th2 response beside specific IgE activation and that a number of other environmental stimuli, such as viruses and pollutants, can trigger the same pattern of inflammation beyond atopy. Emerging data sustain a substantial role of the so-called epithelial dysfunction in asthma pathogenesis, both from anatomic and functional point of view. Furthermore an increasing amount of evidence demonstrates the relevance of innate immunity in polarizing a Th2 impaired response in asthmatic patients. Under this perspective, the complex cross-talking between airway epithelium, innate and adaptive immunity is emerging as a major determinant of type 2-inflammation beyond allergens. This review will include an update on the relevance of dysregulation of innate and adaptive type 2-immunity in asthma pathogenesis, particularly severe asthma, and on the role of the allergens that are associated with severe asthma. Type 2-immunity also will be reviewed in the light of the current and upcoming targeted treatments for severe asthma.
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DOI：
10.1016/j.jaip.2017.02.002
发表时间：
2017-09-01
影响因子：
9.4
作者：
Alhossan, Abdulaziz;Lee, Christopher S.;Abraham, Ivo
通讯作者：
Abraham, Ivo
影响因子：
14.2
作者：
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DOI：
10.1164/ajrccm/146.2.500
发表时间：
1992-08-01
期刊：
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影响因子：
--
作者：
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通讯作者：
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影响因子：
14.2
作者：
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通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
Jacquet, A