Phytoestrogens and breast cancer prevention: possible mechanisms of action.
Phytoestrogens and breast cancer prevention: possible mechanisms of action.
复制标题
植物雌激素和预防乳腺癌：可能的作用机制。
DOI：
10.1289/ehp.10538
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发表时间：
2008-04
影响因子：
10.4
通讯作者：
Bhat HK
中科院分区：
文献类型：
--
作者：
Mense SM;Hei TK;Ganju RK;Bhat HK
植物雌激素显示出一系列药理学特性，近年来对其作为抗癌剂的潜力的研究急剧增加。在本文中，我们回顾了与植物雌激素和乳腺癌相关的已发表文献，并提出了植物雌激素与乳腺癌之间关系的可能机制。 2007年6月在MEDLINE和EMBASE上进行了植物雌激素和乳腺癌的电子检索。电子检索没有日期限制。我们重点关注已发表研究的实验数据，这些研究使用体内或体外模型检查植物雌激素的特性。我们还在本次综述中纳入了人类干预研究。我们评估了有关植物雌激素作用可能机制的证据。对这些机制的讨论分为与雌激素受体、细胞生长和增殖、肿瘤发展、信号传导途径和雌激素代谢酶相关的活动。我们认为，尽管进行了大量研究，但植物雌激素在乳腺癌中的作用机制尚未阐明。目前尚不清楚这些植物化合物是否具有化学保护作用，或者它们是否可能产生与乳腺癌相关的不良后果。
Phytoestrogens display an array of pharmacologic properties, and in recent years investigation of their potential as anticancer agents has increased dramatically. In this article we review the published literature related to phytoestrogens and breast cancer as well as suggest the possible mechanisms that may underlie the relationship between phytoestrogens and breast cancer. Electronic searches on phytoestrogens and breast cancer were performed on MEDLINE and EMBASE in June 2007. No date restriction was placed on the electronic search. We focused on experimental data from published studies that examined the characteristics of phytoestrogens using in vivo or in vitro models. We also include human intervention studies in this review. We evaluated evidence regarding the possible mechanisms of phytoestrogen action. Discussions of these mechanisms were organized into those activities related to the estrogen receptor, cell growth and proliferation, tumor development, signaling pathways, and estrogen-metabolizing enzymes. We suggest that despite numerous investigations, the mechanisms of phytoestrogen action in breast cancer have yet to be elucidated. It remains uncertain whether these plant compounds are chemoprotective or whether they may produce adverse outcomes related to breast carcinogenesis.
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DOI：
10.1016/s0925-4439(03)00082-6
发表时间：
2003-07-14
影响因子：
6.2
作者：
Chen, WF;Huang, MH;Wong, MS
通讯作者：
Wong, MS
DOI：
10.1016/j.jsbmb.2005.02.002
发表时间：
2005-04-01
影响因子：
4.1
作者：
Brooks, JD;Thompson, LU
通讯作者：
Thompson, LU
白藜芦醇抑制人支气管上皮细胞中的苯并[A] pyrene-DNA加合物的形成。
影响因子：
8.8
作者：
Berge, G;Ovrebo, S;Botnen, IV;Hewer, A;Phillips, DH;Haugen, A;Mollerup, S
通讯作者：
Mollerup, S
影响因子：
2.9
作者：
Constantinou, AI;Lantvit, D;Pezzuto, JM
通讯作者：
Pezzuto, JM
影响因子：
3.8
作者：
Balfe, P;McCann, A;Kerin, MJ
通讯作者：
Kerin, MJ