Association between bronchopulmonary dysplasia and cerebral palsy in children: a meta-analysis.
Association between bronchopulmonary dysplasia and cerebral palsy in children: a meta-analysis.
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DOI：
10.1136/bmjopen-2017-020735
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发表时间：
2018-09-19
期刊：
影响因子：
2.9
通讯作者：
Xiao D
中科院分区：
文献类型：
--
作者：
Gou X;Yang L;Pan L;Xiao D
探讨支气管肺发育不良（BPD）与小儿脑瘫（CP）的关系。我们使用EMBASE，PubMed和Web of Science对2017年9月1日之前发表的研究进行荟萃分析，这些研究以英文撰写，其标题或摘要讨论了BPD和CP之间的关联。包括观察性研究，例如病例对照和队列研究。所有审查阶段均由两名审查员独立进行。通过对现有证据的荟萃分析进行数据综合。在暴露于BPD后测量发生CP的患病率。在1234项初步确定的研究中，我们根据预选的纳入标准选择了那些讨论BPD和CP之间相关性的研究。我们的荟萃分析包括11项研究。根据随机效应模型，BPD与早产儿CP显著相关（OR为2.10; 95%CI为1.57 - 2.82）。解释研究结果差异的因素包括研究设计、BPD的定义、CP的诊断时间以及研究是否调整了潜在的混杂因素。这项研究表明，BPD是CP的危险因素。需要进一步的研究来证实这些结果，并检测变量对研究的影响。
To investigate the association between bronchopulmonary dysplasia (BPD) and the risk of cerebral palsy (CP) in children. We used EMBASE, PubMed and Web of Science to conduct a meta-analysis of studies published before 1 September 2017, written in English whose titles or abstracts discussed an association between BPD and CP. Observational studies, for example, case–control and cohort studies were included. All review stages were conducted by two reviewers independently. Data synthesis was undertaken via meta-analysis of available evidence. The prevalence of developing CP was measured after exposure to BPD. Among 1234 initially identified studies, we selected those that addressed an association between BPD and CP according to our preselected inclusion criteria. Our meta-analysis included 11 studies. According to a random effect model, BPD was significantly associated with CP (ORs 2.10; 95% CI 1.57 to 2.82) in preterm infants. Factors explaining differences in the study results included study design, the definition of BPD, the time of diagnosis of CP and whether the studies adjusted for potential confounders. This study suggests that BPD is a risk factor for CP. Further studies are required to confirm these results and to detect the influence of variables across studies.
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