Haemolysis and haem oxygenase-1 induction during persistent "asymptomatic" malaria infection in Burkinabé children.
Haemolysis and haem oxygenase-1 induction during persistent "asymptomatic" malaria infection in Burkinabé children.
复制标题
DOI：
10.1186/s12936-018-2402-6
复制
发表时间：
2018-07-06
期刊：
影响因子：
3
通讯作者：
Riley EM
中科院分区：
文献类型：
--
作者：
Mooney JP;Barry A;Gonçalves BP;Tiono AB;Awandu SS;Grignard L;Drakeley CJ;Bottomley C;Bousema T;Riley EM
与疟疾临床发作相关的溶血导致血红素的释放，从而激活血红素加氧酶-1 （HO-1）。HO-1已被证明可降低中性粒细胞功能并增加对侵袭性细菌疾病的易感性。然而，大多数与社区相关的疟疾感染是亚临床的，通常被称为“无症状”，亚临床疟疾感染期间低度溶血的后果尚不清楚。作为布基纳法索正在进行的亚临床疟疾研究的一部分，将23名亚临床恶性疟原虫感染儿童（通过qPCR确定）与21名与村庄匹配的未感染对照儿童进行了比较。感染儿童表现出持续溶血超过35天的证据，血浆血红素和HO-1浓度升高。与未感染儿童相比，感染儿童的IL-10浓度也更高，IL-10也可以直接激活HO-1。回归分析显示HO-1与溶血有关，但与寄生虫密度、贫血或IL-10浓度无关。这项研究表明，亚临床恶性疟原虫疟疾感染与持续溶血和HO-1的诱导有关。鉴于HO-1、中性粒细胞功能障碍和沙门氏菌血症风险增加之间的关联，长期的HO-1诱导可以解释疟疾和侵袭性细菌疾病之间的流行病学关联和地理重叠。需要进一步研究以了解持续亚临床疟疾感染、低度溶血和HO-1升高对免疫细胞功能和合并症风险的影响。
The haemolysis associated with clinical episodes of malaria results in the liberation of haem, which activates the enzyme haem oxygenase-1 (HO-1). HO-1 has been shown to reduce neutrophil function and increase susceptibility to invasive bacterial disease. However, the majority of community-associated malaria infections are subclinical, often termed “asymptomatic” and the consequences of low-grade haemolysis during subclinical malaria infection are unknown. As part of an ongoing study of subclinical malaria in Burkina Faso, 23 children with subclinical Plasmodium falciparum infections (determined by qPCR) were compared with 21 village-matched uninfected control children. Infected children showed evidence of persistent haemolysis over 35 days, with raised plasma haem and HO-1 concentrations. Concentrations of IL-10, which can also directly activate HO-1, were also higher in infected children compared to uninfected children. Regression analysis revealed that HO-1 was associated with haemolysis, but not with parasite density, anaemia or IL-10 concentration. This study reveals that subclinical P. falciparum malaria infection is associated with sustained haemolysis and the induction of HO-1. Given the association between HO-1, neutrophil dysfunction and increased risk of Salmonella bacteraemia, prolonged HO-1 induction may explain epidemiological associations and geographic overlap between malaria and invasive bacterial disease. Further studies are needed to understand the consequences of persistent subclinical malaria infection, low-grade haemolysis and raised HO-1 on immune cell function and risk of comorbidities.
登录
查看更多内容
影响因子：
15.8
作者：
Chen I;Clarke SE;Gosling R;Hamainza B;Killeen G;Magill A;O'Meara W;Price RN;Riley EM
通讯作者：
Riley EM
影响因子：
6.7
作者：
Lokken KL;Mooney JP;Butler BP;Xavier MN;Chau JY;Schaltenberg N;Begum RH;Müller W;Luckhart S;Tsolis RM
通讯作者：
Tsolis RM
影响因子：
20.3
作者：
Kovtunovych, Gennadiy;Eckhaus, Michael A.;Rouault, Tracey A.
通讯作者：
Rouault, Tracey A.
影响因子：
3
作者：
Gwamaka M;Fried M;Domingo G;Duffy PE
通讯作者：
Duffy PE
影响因子：
168.9
作者：
Clarke, Sian E.;Jukes, Matthew C. H.;Brooker, Simon
通讯作者：
Brooker, Simon