Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia.
Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia.
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DOI：
10.1186/1475-2875-10-386
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发表时间：
2011-12-29
期刊：
影响因子：
3
通讯作者：
Duffy PE
中科院分区：
文献类型：
--
作者：
Gwamaka M;Fried M;Domingo G;Duffy PE
在严重的疟疾贫血期间以及作为细胞衰老过程的一部分，红细胞 (RBC) 表面的补体调节蛋白 (CrP) 水平会降低。目前尚不清楚疟疾期间出现的 CrP 变化是否会导致贫血的发生，或者是由于疟疾对红细胞生成的抑制作用导致红细胞年龄分布改变所致。在坦桑尼亚东北海岸进行了一项横断面研究，旨在调查糖基磷脂酰肌醇 (GPI) 锚定的补体调节蛋白（CD55 和 CD59）的变化是否会导致疟疾贫血。血液样本是从一组接受恶性疟原虫寄生虫血症和疾病严密监测的儿童中采集的。通过流式细胞仪测量CD55和CD59的水平，并在贫血（8.08g/dl）和非贫血儿童（11.42g/dl）之间进行比较。 CD55 和 CD59 的水平随着红细胞年龄的增加而降低。贫血儿童的 CD55 水平较低，并且所有年龄段的红细胞中都存在差异。贫血儿童的 CD59 水平较低，但这些差异并不显着。 CD55（而非 CD59）水平与贫血儿童的血红蛋白水平呈正相关。在疟疾贫血病程早期，所有年龄段的红细胞中 CD55 丢失的程度以及 CD55 与血红蛋白水平的相关性支持了 CD55 可能在这种疾病中起因果作用的假设。
Levels of complement regulatory proteins (CrP) on the surface of red blood cells (RBC) decrease during severe malarial anaemia and as part of cell ageing process. It remains unclear whether CrP changes seen during malaria contribute to the development of anaemia, or result from an altered RBC age distribution due to suppressive effects of malaria on erythropoiesis. A cross sectional study was conducted in the north-east coast of Tanzania to investigate whether the changes in glycosylphosphatidylinositol (GPI)-anchored complement regulatory proteins (CD55 and CD59) contributes to malaria anaemia. Blood samples were collected from a cohort of children under intensive surveillance for Plasmodium falciparum parasitaemia and illness. Levels of CD55 and CD59 were measured by flow cytometer and compared between anaemic (8.08 g/dl) and non- anaemic children (11.42 g/dl). Levels of CD55 and CD59 decreased with increased RBC age. CD55 levels were lower in anaemic children and the difference was seen in RBC of all ages. Levels of CD59 were lower in anaemic children, but these differences were not significant. CD55, but not CD59, levels correlated positively with the level of haemoglobin in anaemic children. The extent of CD55 loss from RBC of all ages early in the course of malarial anaemia and the correlation of CD55 with haemoglobin levels support the hypothesis that CD55 may play a causal role in this disorder.
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影响因子：
20.3
作者：
Omodeo-Salè, F;Motti, A;Taramelli, D
通讯作者：
Taramelli, D
影响因子：
4.4
作者：
Kuttner-Kondo, LA;Mitchell, L;Medof, ME
通讯作者：
Medof, ME
DOI：
10.4269/ajtmh.2005.72.593
发表时间：
2005-05-01
影响因子：
3.3
作者：
Mibei, EK;Orago, ASS;Stoute, JA
通讯作者：
Stoute, JA
影响因子：
6.5
作者：
ABDALLA, S;WEATHERALL, DJ;HUGHES, M
通讯作者：
HUGHES, M
影响因子：
5.4
作者：
Wiesner, J;Jomaa, H;Lanzer, M
通讯作者：
Lanzer, M