Observations of TCRVβ Gene Expression in Rats with Dampness Syndrome.
Observations of TCRVβ Gene Expression in Rats with Dampness Syndrome.
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DOI：
10.1155/2014/373608
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Xiang T
中科院分区：
文献类型：
--
作者：
Chen Y;Sun BG;Zhang SJ;Chen ZX;Hardi CF;Xiang T
环境潮湿是引起人体疾病的因素之一。暴露于湿度对人体免疫功能的影响是多种多样的。在中医理论中，湿气被定义为人体的主要致病因素之一。分为“外湿”和“内湿”。然而，导致湿度诱导的免疫抑制的分子机制尚不清楚。在本研究中，我们研究了在不同潮湿环境下喂养的大鼠中T细胞抗原受体变量β（TCRVβ）亚家族的表达。采用FQ-PCR检测TCRVβ亚家族的表达水平。我们发现湿气可能会降低大鼠的免疫识别功能。而免疫识别功能的障碍可能是内湿所致，而不是外湿所致。
Environmental dampness is one factor which can cause human diseases. The effects of exposure to humidity on human immune function are diverse and numerous. In the theory of traditional Chinese medicine (TCM), dampness is defined as one of the major pathogenic factors in the human body. It is divided into “external dampness” and “internal dampness.” However the molecular mechanism leading to humidity-induced immunosuppression is obscure. In the present study, we investigated the expression of the T-cell antigen receptor variable β (TCRVβ) subfamilies in rats which were fed in different humid environment. And the expression levels of the TCRVβ subfamilies were detected using FQ-PCR. We found that the dampness might reduce the immunological recognition function of rats. And the obstruction of the immunological recognition function might be caused by internal dampness rather than external dampness.
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