Circulating miR-185 might be a novel biomarker for clinical outcome in patients with dilated cardiomyopathy.
Circulating miR-185 might be a novel biomarker for clinical outcome in patients with dilated cardiomyopathy.
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循环 miR-185 可能是扩张型心肌病患者临床结果的新型生物标志物
DOI：
10.1038/srep33580
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发表时间：
2016-09-20
影响因子：
4.6
通讯作者：
Yuan J
中科院分区：
文献类型：
--
作者：
Yu M;Liang W;Xie Y;Long Q;Cheng X;Liao YH;Yuan J
B细胞通过诱导心肌细胞损伤和心肌纤维化而促进扩张型心肌病（DCM）的发展。我们最近的研究表明microRNA（miR）-185参与了人类B细胞的活化。因此，本研究旨在探讨miR-185与DCM进展的关系。41名健康志愿者和50名新诊断的DCM患者入组。检测血浆miR-185、分泌TNF-α的B细胞和抗心脏自身抗体水平。我们发现DCM患者血浆miR-185的平均水平显著高于健康对照组。此外，根据miR-185的聚集分布，可将DCM患者分为miR-185高表达组和miR-185低表达组。在一年的随访期间，miR-185高组显示左心室射血分数、左心室舒张末期直径和NT-proBNP明显改善，同时心血管死亡率和心力衰竭再住院总住院率显著下降。此外，miR-185高表达组抗β1-AR抗体和分泌TNF-α的B细胞水平也明显降低。这些发现表明，高miR-185水平可能通过抑制DCM中的B细胞功能而与良好的预后相关。本研究的结果需要更大的样本量和更长的观察时间来证实。
B cells contribute to the development of dilated cardiomyopathy (DCM) by inducing myocyte injuries and myocardial fibrosis. Our recent research indicated that microRNA (miR) -185 participated in human B-cell activation. Thus, this study was aimed to explore the relationship between miR-185 and DCM progression. Forty-one healthy volunteers and fifty newly diagnosed DCM patients were enrolled. The levels of plasma miR-185, TNF-α secreting B cells and anti-heart autoantibody were detected. We found that the mean levels of plasma miR-185 in DCM patients were significantly higher than those in healthy controls. Furthermore, these DCM patients could be divided into miR-185highand miR-185lowgroups according to the cluster distribution. During one-year follow-up period, the miR-185highgroup showed apparent improvements in left ventricular ejection fraction, left ventricular end diastolic diameter and NT-proBNP, accompanied by significant declines in both cardiovascular mortality and total admissions for heart failure re-hospitalizations. In addition, the levels of anti-β1-AR antibody and TNF-α secreting B cells were also reduced in miR-185highgroup. These findings suggested that high miR-185 levels might be associated with a favorable prognosis by repressing B cell function in DCM. The findings of this study need to be confirmed with larger sample size and longer duration of observation.
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DOI：
10.1016/j.clim.2013.01.011
发表时间：
2013-04
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
de la Morena MT;Eitson JL;Dozmorov IM;Belkaya S;Hoover AR;Anguiano E;Pascual MV;van Oers NSC
通讯作者：
van Oers NSC
影响因子：
7
作者：
Baumjohann D;Ansel KM
通讯作者：
Ansel KM
影响因子：
3.5
作者：
Watson, Chris J.;Collier, Patrick;Baugh, John A.
通讯作者：
Baugh, John A.
影响因子：
168.9
作者：
Habib, FM;Springall, DR;Polak, JM
通讯作者：
Polak, JM
影响因子：
6
作者：
Qadir, Ximena V.;Han, Chang;Wu, Tong
通讯作者：
Wu, Tong