Association between single-slice measurements of visceral and abdominal subcutaneous adipose tissue with volumetric measurements: the Framingham Heart Study.
Association between single-slice measurements of visceral and abdominal subcutaneous adipose tissue with volumetric measurements: the Framingham Heart Study.
复制标题
DOI：
10.1038/ijo.2009.279
复制
发表时间：
2010-04
影响因子：
4.9
通讯作者：
Fox, C. S.
中科院分区：
文献类型：
--
作者：
Irlbeck, T.;Massaro, J. M.;Bamberg, F.;O'Donnell, C. J.;Hoffmann, U.;Fox, C. S.
关键词：
通过计算机断层扫描（CT）测量的腹部内脏脂肪组织（VAT）和腹部皮下脂肪组织（SAT）与代谢风险因素相关。我们试图确定VAT和SAT之间的相关性，在不同的解剖位置与体积测量的面积为基础的措施，以确定最佳的解剖部位，并在该网站与代谢危险因素的测量。我们测量了整个成像体积中的SAT和VAT体积，而我们测量了来自心脏研究的200名参与者（平均年龄54岁，50%为女性）的7个预定义解剖标志处的SAT和VAT面积，这些参与者接受了腹部多探测器CT。相关系数用于评估面积测量值和体积以及按性别分层的代谢风险因素之间的关联。在所有解剖标志处获得的基于面积的SAT和VAT测量值与SAT和VAT体积密切相关（女性和男性分别为r>0.93，P <0.0001 and r>0.87，P<0.0001）。一致的是，在L3/4获得的基于面积的SAT和VAT测量值与体积测量的VAT和SAT的相关性最强，与年龄无关（男性r=0.99，女性SAT r=0.96，VAT r=0.99，所有P值<0.0001），与SAT和VAT体积相比，与风险因素相关性相似（空腹血糖、甘油三酯、高密度脂蛋白、收缩压均P<0.05）。在基于面积的SAT和VAT测量中，在L3/4水平获得的测量结果与SAT和VAT体积以及男性和女性的心脏代谢危险因素密切相关。
Volumetric visceral abdominal adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAT) as measured by computed tomography (CT) are associated with metabolic risk factors. We sought to identify the correlations of VAT and SAT between area-based measures at different anatomic locations with volumetric measurements to identify the optimal anatomic site, and to relate measurements at this site with metabolic risk factors. We measured SAT and VAT volumes across the total imaging volume, whereas we measured SAT and VAT area at seven predefined anatomic landmarks in 200 participants from the Framingham Heart Study (mean age 54 years, 50% women) who underwent abdominal multi-detector CT. Correlation coefficients were used to assess the association between area measurements and volumes as well as metabolic risk factors stratified by gender. Area-based measurements of SAT and VAT obtained at all anatomic landmarks were strongly associated with SAT and VAT volumes (all r>0.93, P<0.0001 and r>0.87, P<0.0001, for women and men; respectively). Consistently, area-based measurements of SAT and VAT obtained at L3/4 were most strongly associated with volumetric measured VAT and SAT independent of age (both r=0.99 in men, r=0.96 for SAT and r=0.99 for VAT in women, all P-value <0.0001) and were similarly correlated with risk factors compared with SAT and VAT volumes (all P<0.05 for fasting plasma glucose, triglycerides, high-density lipoprotein, systolic blood pressure). Among area-based measurements of SAT and VAT, those obtained at the level of L3/4 were strongly associated with SAT and VAT volumes and cardio-metabolic risk factors in both men and women.
登录
查看更多内容
影响因子：
120.7
作者：
Hedley, AA;Ogden, CL;Flegal, KM
通讯作者：
Flegal, KM
影响因子：
7.1
作者：
BORKAN, GA;GERZOF, SG;SILBERT, JE
通讯作者：
SILBERT, JE
影响因子：
16.2
作者：
Kuk, JL;Church, TS;Ross, R
通讯作者：
Ross, R
影响因子：
37.8
作者：
Rosito, Guido A.;Massaro, Joseph M.;Fox, Caroline S.
通讯作者：
Fox, Caroline S.
影响因子：
4.9
作者：
Han, TS;McNeill, G;Lean, MEJ
通讯作者：
Lean, MEJ