Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology.
Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology.
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DOI：
10.1016/j.mam.2008.08.004
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发表时间：
2009-02
影响因子：
10.6
通讯作者：
Hammond, Christine L.
中科院分区：
文献类型：
--
作者：
Ballatori, Nazzareno;Krance, Suzanne M.;Marchan, Rosemarie;Hammond, Christine L.
关键词：
还原性谷胱甘肽（GSH）对许多细胞过程至关重要，其细胞内和细胞外浓度都受到严格调节。细胞内谷胱甘肽水平受两种主要机制调节：通过调节合成速率和细胞输出速率。一些负责从哺乳动物细胞中输出谷胱甘肽的蛋白质最近已经被确定，并且有越来越多的证据表明这些谷胱甘肽输出是多特异性和多功能的，调节了许多关键的生物过程。特别是，多药耐药相关蛋白（Mrp/Abcc）似乎介导谷胱甘肽的输出和体内平衡。Mrp蛋白不仅介导谷胱甘肽外排，而且还输出氧化谷胱甘肽衍生物（如谷胱甘肽二硫（GSSG）、s -亚硝基谷胱甘肽（GS-NO）和谷胱甘肽-金属配合物），以及其他谷胱甘肽s -缀合物。输出谷胱甘肽和谷胱甘肽的氧化衍生物的能力，赋予这些转运体直接调节细胞硫醇氧化还原状态的能力，因此能够影响许多关键的信号传导和生化途径。受谷胱甘肽转运体影响的许多过程包括细胞凋亡、细胞增殖和细胞分化。本报告总结了Mrps有助于调节细胞GSH水平和硫醇氧化还原状态的证据，从而影响了受该三肽影响的许多生化过程。
Reduced glutathione (GSH) is critical for many cellular processes, and both its intracellular and extracellular concentrations are tightly regulated. Intracellular GSH levels are regulated by two main mechanisms: by adjusting the rates of synthesis and of export from cells. Some of the proteins responsible for GSH export from mammalian cells have recently been identified, and there is increasing evidence that these GSH exporters are multispecific and multifunctional, regulating a number of key biological processes. In particular, the multidrug resistance-associated proteins (Mrp/Abcc) appear to mediate GSH export and homeostasis. The Mrp proteins mediate not only GSH efflux, but they also export oxidized glutathione derivatives (e.g., glutathione disulfide (GSSG), S-nitrosoglutathione (GS-NO), and glutathione-metal complexes), as well as other glutathione S-conjugates. The ability to export both GSH and oxidized derivatives of GSH, endows these transporters with the capacity to directly regulate the cellular thiol-redox status, and therefore the ability to influence many key signaling and biochemical pathways. Among the many processes that are influenced by the GSH transporters are apoptosis, cell proliferation, and cell differentiation. This report summarizes the evidence that Mrps contribute to the regulation of cellular GSH levels and the thiol redox state, and thus to the many biochemical processes that are influenced by this tripeptide.
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影响因子：
--
作者：
BALLATORI, N;TRUONG, AT;BOYER, JL
通讯作者：
BOYER, JL
影响因子：
4.3
作者：
Benard, O;Balasubramanian, KA
通讯作者：
Balasubramanian, KA
DOI：
10.1093/jnci/90.22.1735
发表时间：
1998-11-18
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Belinsky, MG;Bain, LJ;Kruh, GD
通讯作者：
Kruh, GD
影响因子：
2.3
作者：
Beck, K;Hayashi, K;Boyd, CD
通讯作者：
Boyd, CD
影响因子：
4.1
作者：
Bojes, HK;Datta, K;Kehrer, JP
通讯作者：
Kehrer, JP