Maternal obesity and high-fat diet program offspring metabolic syndrome.
Maternal obesity and high-fat diet program offspring metabolic syndrome.
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DOI：
10.1016/j.ajog.2014.03.025
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发表时间：
2014-09
影响因子：
9.8
通讯作者：
Ross, Michael G.
中科院分区：
文献类型：
--
作者：
Desai, Mina;Jellyman, Juanita K.;Han, Guang;Beall, Marie;Lane, Robert H.;Ross, Michael G.
我们确定了母亲在怀孕和/或哺乳期间肥胖和高脂肪（HF）饮食对后代代谢综合征的潜在编程影响。在妊娠和哺乳期之前和整个期间，使用HF饮食建立母体肥胖大鼠模型。出生时，对幼仔进行交叉饲养，从而产生妊娠/哺乳期间母体饮食的四种范例：（1）妊娠和哺乳期间对照（Con）饮食- Con/Con，（2）妊娠和哺乳期间HF- HF/HF，（3）仅妊娠期间HF- HF/Con，以及（4）仅哺乳期间HF- Con/HF。妊娠期和哺乳期结束时的母体表型证明HF母鼠的体脂和血浆皮质酮水平显著升高。在后代中，母亲HF饮食在怀孕期间单独编程增加后代肥胖，虽然体重正常，而母亲HF饮食在哺乳期增加体重和肥胖。代谢紊乱，特别是高血糖症，在暴露于母体HF饮食（妊娠期和/或哺乳期）的所有组中均明显，尽管胰岛素抵抗与胰岛素缺乏表型的表现存在明显差异。收缩压升高在所有组中都很明显，这意味着暴露于肥胖/HF环境对后代健康不利，无论妊娠期或哺乳期如何。尽管如此，潜在的机制可能有所不同，因为在子宫内经历HF暴露的后代皮质酮水平增加。母亲肥胖/HF饮食显著影响后代的身体组成和代谢综合征的风险，这取决于怀孕和/或哺乳期间的暴露时间。
We determined the potential programming effects of maternal obesity and high fat (HF) diet during pregnancy and/or lactation on offspring metabolic syndrome. A rat model of maternal obesity was created using a HF diet prior to and throughout pregnancy and lactation. At birth, pups were cross fostered thereby generating four paradigms of maternal diets during pregnancy/lactation: (1) control (Con) diet during pregnancy and lactation - Con/Con, (2), HF during pregnancy and lactation - HF/HF, (3) HF during pregnancy alone - HF/Con, and (4) HF during lactation alone - Con/HF. Maternal phenotype during pregnancy and the end of lactation evidenced markedly elevated body fat and plasma corticosterone levels in HF dams. In the offspring, maternal HF diet during pregnancy alone programmed increased offspring adiposity, though with normal body weight, whereas maternal HF diet during lactation increased both body weight and adiposity. Metabolic disturbances, particularly that of hyperglycemia, were apparent in all groups exposed to maternal HF diet (during pregnancy and/or lactation), though differences were apparent in the manifestation of insulin resistant versus insulin deficient phenotypes. Elevated systolic blood pressure was manifest in all groups implying that exposure to an obese/HF environment is disadvantageous for offspring health, regardless of pregnancy or lactation periods. Nonetheless, the underlying mechanism may differ as offspring that experienced in utero HF exposure had increased corticosterone levels. Maternal obesity/HF diet markedly impact offspring body composition and the risk of metabolic syndrome dependent upon period of exposure during pregnancy and/or lactation.
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影响因子：
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作者：
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DOI：
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2012-04-01
影响因子：
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DOI：
10.1152/ajpendo.00137.2004
发表时间：
2004-11-01
影响因子：
5.1
作者：
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