The role of the 5-HTTLPR polymorphism in acquired capability for suicide.
The role of the 5-HTTLPR polymorphism in acquired capability for suicide.
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5-HTTLPR 多态性在获得性自杀能力中的作用
DOI：
10.1111/sltb.12660
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发表时间：
2020
影响因子：
3.2
通讯作者：
Paashaus
中科院分区：
文献类型：
--
作者：
Wannemueller;Forkmann;Glaesmer;Juckel;Paashaus
根据自杀的人际心理理论，自杀能力包括两个方面：对死亡的恐惧和对疼痛的耐受力。5-羟色胺转运体基因连锁多态性区域（5-HTTLPR）的短（S）等位基因变体一再与更暴力和致命的自杀方法和自杀企图的致命性相关。目前的研究旨在调查是否5-HTTLPR等位基因变异与无畏的死亡和疼痛耐受性/持久性，以及是否它缓和儿童虐待和后天能力之间的关系suicid.MethodA队列的208例住院患者住院，由于最近的自杀企图或严重的自杀意念进行基因分型的5-HTTLPR和评估儿童虐待。主观的疼痛耐受性和对死亡的恐惧以及客观的疼痛持续性进行了评估，使用压力algometer.ResultsFearlessness对死亡，疼痛耐受性和疼痛持续性之间没有差异5-HTTLPR基因型。然而，有一个显着的相关性之间的自我报告的童年虐待和无所畏惧的死亡，出现在纯合子S-等位基因carriers.ConclusionResults表明，有没有“高风险”-等位基因，一般增加自杀的能力。然而，在未来的自杀相关行为方面，暴露于童年虐待事件可能会对纯合子S等位基因携带者产生特别负面的影响，增加他们对死亡的恐惧。
ObjectiveAccording to the Interpersonal Psychological Theory of Suicide, capability for suicide comprises two dimensions: fearlessness about death and elevated pain tolerance. The short (S) allelic variant of the serotonin transporter gene‐linked polymorphic region (5‐HTTLPR) has repeatedly been associated with more violent and lethal suicide methods and lethality of suicide attempts. The current study aimed to investigate whether 5‐HTTLPR allelic variants are associated with fearlessness about death and pain tolerance/persistence and whether it moderates the relationship between childhood maltreatment and acquired capability for suicide.MethodA cohort of 208 inpatients hospitalized due to a recent suicide attempt or severe suicidal ideation was genotyped for the 5‐HTTLPR and assessed for childhood maltreatment. Subjective pain tolerance and fearlessness about death as well as objective pain persistence was assessed using a pressure algometer.ResultsFearlessness about death, pain tolerance, and pain persistence did not differ between 5‐HTTLPR genotypes. However, there was a significant correlation between self‐reported childhood maltreatment and fearlessness about death that emerged exclusively in homozygous S‐allele carriers.ConclusionResults suggest that there are no “high‐risk”‐alleles that generally increase capability for suicide. However, in terms of future suicide‐related behaviors exposure to childhood maltreatment events could exert a particularly negative influence on homozygous S‐allele carriers by increasing their fearlessness about death.
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影响因子：
11
作者：
通讯作者：
--
德国自杀能力问卷的验证和心理测量特性。
影响因子：
7.3
作者：
Sarah Wachtel;S. Vocks;Marc;P. Nyhuis;U. Willutzki;T. Teismann
通讯作者：
T. Teismann
德国版痛苦和挑衅事件量表：心理测量调查
影响因子：
11.3
作者：
T. Teismann;T. Forkmann;Sarah Wachtel;Marc;P. Nyhuis;H. Glaesmer
通讯作者：
H. Glaesmer
影响因子：
6.6
作者：
Brailovskaia, Julia;Forkmann, Thomas;Teismann, Tobias
通讯作者：
Teismann, Tobias
获得的自杀能力、疼痛耐受性和对疼痛的无畏感——德国自杀能力问卷疼痛耐受量表的验证。
影响因子：
3.2
作者：
Sarah Wachtel;Paula Siegmann;Cäcilia Ocklenburg;Lisa Hebermehl;U. Willutzki;T. Teismann
通讯作者：
T. Teismann