Abnormally reduced dorsomedial prefrontal cortical activity and effective connectivity with amygdala in response to negative emotional faces in postpartum depression.
Abnormally reduced dorsomedial prefrontal cortical activity and effective connectivity with amygdala in response to negative emotional faces in postpartum depression.
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DOI：
10.1176/appi.ajp.2010.09081235
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Phillips ML
中科院分区：
文献类型：
--
作者：
Moses-Kolko EL;Perlman SB;Wisner KL;James J;Saul AT;Phillips ML
产后重度抑郁症是一个严重的公共卫生问题，影响了15%的新妈妈，给母亲、孩子和家庭带来了不良后果。产后抑郁症的神经机制尚不清楚，但大脑对情感刺激的处理似乎与其他情感障碍有关。作者检查了背内侧前额叶皮层和杏仁核对消极情绪面孔的反应活动，这是对母性和抑郁都很重要的关键情绪调节神经区域。产后健康母亲（N=16）和未服药的抑郁母亲（N=14）在块设计的面部与形状匹配任务中接受了功能磁共振成像血氧水平依赖性获取。进行了双向方差分析，检查了条件和组以及组与组之间的相互作用对双侧背内侧前额皮质和杏仁核感兴趣区域活动的主要影响。与健康母亲相比，抑郁母亲的左背内侧前额叶皮层面部相关活动显著减少。在抑郁母亲中，左侧杏仁核活动与产后抑郁严重程度呈显著负相关，右侧杏仁核活动与婴儿相关敌意的缺失呈显著正相关。在健康而非抑郁的母亲中，从左背内侧前额叶皮层到左杏仁核存在可靠的自上而下的连接。产后抑郁的一个重要的神经机制或效应是，消极情绪面孔对背内侧前额叶皮层活动的显著减弱和背内侧前额叶皮层-杏仁核有效连接的显著减弱。产后抑郁症母亲面对消极情绪时杏仁核活动的减少与产后抑郁症严重程度和依恋过程受损有关。
Postpartum major depression is a significant public health problem that strikes 15% of new mothers and confers adverse consequences for mothers, children, and families. The neural mechanisms involved in postpartum depression remain unknown, but brain processing of affective stimuli appears to be involved in other affective disorders. The authors examined activity in response to negative emotional faces in the dorsomedial prefrontal cortex and amygdala, key emotion regulatory neural regions of importance to both mothering and depression. Postpartum healthy mothers (N=16) and unmedicated depressed mothers (N=14) underwent functional magnetic resonance imaging blood-oxygen-level-dependent acquisition during a block-designed face versus shape matching task. A two-way analysis of variance was performed examining main effects of condition and group and group-by-condition interaction on activity in bilateral dorsomedial prefrontal cortical and amygdala regions of interest. Depressed mothers relative to healthy mothers had significantly reduced left dorsomedial prefrontal cortical face-related activity. In depressed mothers, there was also a significant negative correlation between left amygdala activity and postpartum depression severity and a significant positive correlation between right amygdala activity and absence of infant-related hostility. There was reliable top-down connectivity from the left dorsomedial prefrontal cortex to the left amygdala in healthy, but not depressed, mothers. Significantly diminished dorsomedial prefrontal cortex activity and dorsomedial prefrontal cortical-amygdala effective connectivity in response to negative emotional faces may represent an important neural mechanism, or effect, of postpartum depression. Reduced amygdala activity in response to negative emotional faces is associated with greater postpartum depression severity and more impaired maternal attachment processes in postpartum depressed mothers.
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通讯作者：
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