A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury.
A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury.
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杏仁核在轻度创伤性脑损伤后情感行为障碍中的作用
DOI：
10.3389/fnbeh.2021.601275
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发表时间：
2021
影响因子：
3
通讯作者：
Raghupathi R
中科院分区：
文献类型：
--
作者：
McCorkle TA;Barson JR;Raghupathi R
轻度创伤性脑损伤（TBI）导致慢性情感障碍，如抑郁、焦虑和恐惧，这些情感障碍在损伤后持续多年，并显著损害患者的生活质量。虽然大量的研究有助于定义轻度TBI的症状，但对于脑损伤的个体没有足够的药物治疗。临床前研究已经模拟了这些损伤后情感行为的缺陷，以了解潜在的机制，从而制定适当的治疗策略。这些研究还揭示了导致与每种行为相关的不同表型的性别差异。尽管临床和临床前研究将这些行为缺陷视为具有独特神经生物学机制的独立实体，但机制相似性表明需要一种新的方法来推进药物治疗研究。这篇综述将讨论在人类和动物的轻度TBI后，情感行为的缺陷的表达所涉及的电路，并提供证据表明，这些行为的损害的表现源于杏仁核依赖的情绪处理缺陷。它将突出这些不同类型的情感行为之间的机制相似性，这些情感行为可以通过研究情感行为缺陷的治疗来潜在地推进轻度TBI药物治疗，作为一个实体，需要相同的治疗。
Mild traumatic brain injury (TBI) results in chronic affective disorders such as depression, anxiety, and fear that persist up to years following injury and significantly impair the quality of life for patients. Although a great deal of research has contributed to defining symptoms of mild TBI, there are no adequate drug therapies for brain-injured individuals. Preclinical studies have modeled these deficits in affective behaviors post-injury to understand the underlying mechanisms with a view to developing appropriate treatment strategies. These studies have also unveiled sex differences that contribute to the varying phenotypes associated with each behavior. Although clinical and preclinical studies have viewed these behavioral deficits as separate entities with unique neurobiological mechanisms, mechanistic similarities suggest that a novel approach is needed to advance research on drug therapy. This review will discuss the circuitry involved in the expression of deficits in affective behaviors following mild TBI in humans and animals and provide evidence that the manifestation of impairment in these behaviors stems from an amygdala-dependent emotional processing deficit. It will highlight mechanistic similarities between these different types of affective behaviors that can potentially advance mild TBI drug therapy by investigating treatments for the deficits in affective behaviors as one entity, requiring the same treatment.
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DOI：
10.1016/b978-0-444-63954-7.00007-0
发表时间：
2018-01-01
期刊：
SPORTS NEUROLOGY
影响因子：
--
作者：
Baldwin, Grant T.;Breiding, Matthew J.;Comstock, R. Dawn
通讯作者：
Comstock, R. Dawn
影响因子：
6.9
作者：
Bremner, JD;Vermetten, E;Charney, DS
通讯作者：
Charney, DS
影响因子：
11
作者：
通讯作者：
--
影响因子：
4.1
作者：
BEAULIEU, S;DIPAOLO, T;BARDEN, N
通讯作者：
BARDEN, N
影响因子：
3.3
作者：
Chen, Y. -W.;Rada, P. V.;Hoebel, B. G.
通讯作者：
Hoebel, B. G.