Postoperative Ileus after Stimulation with Probiotics before Ileostomy Closure.
Postoperative Ileus after Stimulation with Probiotics before Ileostomy Closure.
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DOI：
10.3390/nu13020626
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发表时间：
2021-02-15
期刊：
影响因子：
5.9
通讯作者：
Ruiz-Frutos C
中科院分区：
文献类型：
--
作者：
Rodríguez-Padilla Á;Morales-Martín G;Pérez-Quintero R;Gómez-Salgado J;Balongo-García R;Ruiz-Frutos C
结直肠手术后回肠闭合常与术后肠梗阻有关，发生率在13-20%之间。本研究的目的是评价结直肠癌手术患者回肠造口前应用益生菌刺激出流环的有效性和安全性。为此，设计了一项前瞻性、随机、双盲、对照研究。所有接受结肠直肠癌回肠环形造口手术的患者均纳入研究。随机分为两组，34例患者和35例对照组。评估了术后肠梗阻、插入鼻胃管的必要性、开始耐受饮食所需的时间、肠功能恢复以及住院时间。两组患者术后肠梗阻发生率相似，9/34例患者接受益生菌刺激，10/35例对照组(CG)，P=0.192。对比分析表明，肿瘤术后肠梗阻与重建术后肠梗阻有直接关系，与刺激无关。闭合回肠造口术后的肠梗阻不依赖于通过传出环使用益生菌的回肠造口的刺激。结直肠癌术后肠梗阻的存在与重建术后肠梗阻似乎有一定的关系。
Loop ileostomy closure after colorectal surgery is often associated with Postoperative ileus, with an incidence between 13–20%. The aim of this study is to evaluate the efficacy and safety of preoperative stimulation of the efferent loop with probiotics prior to ileostomy closure in patients operated on for colorectal carcinoma. For this, a prospective, randomized, double-blind, controlled study is designed. All patients who underwent surgery for colorectal carcinoma with loop ileostomy were included. Randomized and divided into two groups, 34 cases and 35 controls were included in the study. Postoperative ileus, the need for nasogastric tube insertion, the time required to begin tolerating a diet, restoration of bowel function, and duration of hospital stay were evaluated. The incidence of Postoperative ileus was similar in both groups, 9/34 patients stimulated with probiotics and 10/35 in the control group (CG) with a p = 0.192. The comparative analysis showed a direct relationship between Postoperative ileus after oncological surgery and Postoperative ileus after reconstruction surgery, independently of stimulation. Postoperative ileus after closure ileostomy is independent of stimulation of the ileostomy with probiotics through the efferent loop. There seem to be a relationship between Postoperative ileus after reconstruction and the previous existence of Postoperative ileus after colorectal cancer surgery.
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DOI：
10.1007/s00464-019-07011-6
发表时间：
2020-05-01
影响因子：
3.1
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