Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation.
Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation.
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肠道菌群与溃疡性结肠炎的关系：益生菌和粪便菌群移植的机制及临床应用
DOI：
10.3748/wjg.v24.i1.5
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发表时间：
2018-01-07
影响因子：
4.3
通讯作者：
Wang XY
中科院分区：
文献类型：
--
作者：
Shen ZH;Zhu CX;Quan YS;Yang ZY;Wu S;Luo WW;Tan B;Wang XY
溃疡性结肠炎(UC)是一种主要影响结肠和直肠的炎症性疾病。目前认为遗传因素、宿主免疫系统紊乱、肠道微生物区系失调和环境因素参与了UC的发病。然而，关于肠道微生物区系在UC发病机制中的作用的研究一直没有定论。研究表明，益生菌可改善肠粘膜屏障功能和免疫系统功能，促进抗炎因子的分泌，从而抑制肠道有害细菌的生长。粪便微生物区系移植(FMT)可以通过增加短链脂肪酸的产生来降低肠道通透性，从而降低疾病的严重程度，特别是丁酸，这有助于维持上皮屏障的完整性。FMT还可以通过抑制Th1分化、T细胞活性、白细胞黏附和炎症因子的产生来恢复免疫失调。益生菌和FMT正越来越多地用于治疗UC，但由于疗效不确定，它们的使用存在争议。在这里，我们简要回顾肠道微生物区系在UC发病机制和治疗中的作用。
Ulcerative colitis (UC) is an inflammatory disease that mainly affects the colon and rectum. It is believed that genetic factors, host immune system disorders, intestinal microbiota dysbiosis, and environmental factors contribute to the pathogenesis of UC. However, studies on the role of intestinal microbiota in the pathogenesis of UC have been inconclusive. Studies have shown that probiotics improve intestinal mucosa barrier function and immune system function and promote secretion of anti-inflammatory factors, thereby inhibiting the growth of harmful bacteria in the intestine. Fecal microbiota transplantation (FMT) can reduce bowel permeability and thus the severity of disease by increasing the production of short-chain fatty acids, especially butyrate, which help maintain the integrity of the epithelial barrier. FMT can also restore immune dysbiosis by inhibiting Th1 differentiation, activity of T cells, leukocyte adhesion, and production of inflammatory factors. Probiotics and FMT are being increasingly used to treat UC, but their use is controversial because of uncertain efficacy. Here, we briefly review the role of intestinal microbiota in the pathogenesis and treatment of UC.
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影响因子：
15.3
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.2
作者：
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通讯作者：
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