Identification of a sensitive period of prenatal cocaine exposure that alters the development of the anterior cingulate cortex.
Identification of a sensitive period of prenatal cocaine exposure that alters the development of the anterior cingulate cortex.
复制标题
确定产前可卡因暴露改变前扣带皮层发育的敏感期。
DOI：
10.1093/cercor/11.5.430
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Levitt,P
中科院分区：
文献类型：
--
作者：
Stanwood,GD;Washington,RA;Levitt,P
Administration of cocaine to pregnant rabbits produces robust and long-lasting anatomical, neurochemical and behavioral alterations in their offspring. For example, exposure to cocaine following implantation [embryonic day (E) 8] through gestation (E29) produces increased length and decreased bundling of layer III and V pyramidal neuron dendrites, increased parvalbumin expression in the dendrites of interneurons, and increased GABA levels in the anterior cingulate cortex (ACC) and other dopamine-rich cortical areas. We have investigated the presence of a sensitive period ofin uteroexposure during specific developmental epochs prior to and during the onset of cortical development that might be capable of producing such effects. Cocaine (3 mg/kg i.v., twice daily) or saline was administered during embryonic days E16–E25 (onset and peak of corticogenesis), E8–E15 (prior to cortical plate formation), E8–E25 or E8–E29 as in earlier studies. Examination of the ACC in offspring exposed from E8 to E25 and from E16 to E25 were found to induce alterations in the development of pyramidal neurons and interneurons that are nearly identical to those induced by the complete exposure (E8–E29) paradigm. No alterations were observed following the E8–E15 cocaine exposure. These data suggest that exposure to cocaine during E16–E25, the time of peak corticogenesis, appearance of cortical monoamines and onset of D1dopamine receptor expression, is necessary and sufficient to produce long-term effects on the organization of excitatory pyramidal neurons and inhibitory interneurons in the ACC.
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恒河猴胎儿长期接触可卡因：对多巴胺神经元早期发育的影响
影响因子：
1.9
作者：
O. Rønnekleiv;B. Naylor
通讯作者：
B. Naylor
产前接触可卡因
影响因子：
5.2
作者：
R. Keller;A. Snyder
通讯作者：
A. Snyder
影响因子：
2.9
作者：
ANDERSONBROWN, T;SLOTKIN, TA;SEIDLER, FJ
通讯作者：
SEIDLER, FJ
在不同的暴露时期和母体血浆可卡因浓度下，在子宫内每天多次剂量地接触可卡因后，会出现长期学习缺陷和未习得行为的变化。
影响因子：
2.9
作者：
Vorhees,CV;Reed,TM;Acuff-Smith,KD;Schilling,MA;Cappon,GD;Fisher,JE;Pu,C
通讯作者：
Pu,C
兔子作为子宫内可卡因暴露研究的模型。
DOI：
--
发表时间：
1995
期刊：
Laboratory animal science.
影响因子：
--
作者：
Murphy,EH;Hammer,JG;Schumann,MD;Groce,MY;Wang,XH;Jones,L;Romano,AG;Harvey,JA
通讯作者：
Harvey,JA