Progress towards the development of a P. vivax vaccine.
Progress towards the development of a P. vivax vaccine.
复制标题
研制间日疟原虫疫苗的进展。
DOI：
10.1080/14760584.2021.1880898
复制
发表时间：
2021-03
影响因子：
6.2
通讯作者：
Adams JH
中科院分区：
文献类型：
--
作者：
De SL;Ntumngia FB;Nicholas J;Adams JH
间日疟原虫在流行地区引起严重的公共卫生问题。考虑到抗药性寄生虫菌株的快速传播以及肝脏中催眠虫的发展具有复发的潜力，预防疾病的疫苗至关重要。最低限度有效的疫苗应该预防疾病和传播，而理想的疫苗提供无菌免疫。尽管进行了数十年的研究，但复杂的生命周期、技术挑战和缺乏资金阻碍了间日疟原虫疫苗开发的进展。在这里，我们回顾了来自寄生虫生命周期不同阶段的潜在间日疟原虫疫苗候选者的进展。我们还强调了合理疫苗设计的挑战和重要策略。这些因素可以显著增加免疫效应机制，并提高这些候选药物在临床试验中的保护效力，以在更长时间内产生持续保护。从寄生虫生命周期的各个阶段的多种抗原中呈递功能保守表位的疫苗是诱导广泛中和的超越菌株的保护性免疫以有效地破坏寄生虫发育和传播的关键。
Plasmodium vivax causes significant public health problems in endemic regions. A vaccine to prevent disease is critical, considering the rapid spread of drug-resistant parasite strains, and the development of hypnozoites in the liver with potential for relapse. A minimally effective vaccine should prevent disease and transmission while an ideal vaccine provides sterile immunity. Despite decades of research, the complex life cycle, technical challenges and a lack of funding have hampered progress of P. vivax vaccine development. Here, we review the progress of potential P. vivax vaccine candidates from different stages of the parasite life cycle. We also highlight the challenges and important strategies for rational vaccine design. These factors can significantly increase immune effector mechanisms and improve the protective efficacy of these candidates in clinical trials to generate sustained protection over longer periods of time. A vaccine that presents functionally-conserved epitopes from multiple antigens from various stages of the parasite life cycle is key to induce broadly neutralizing strain-transcending protective immunity to effectively disrupt parasite development and transmission.
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影响因子：
3.7
作者：
Arévalo-Herrera M;Forero-Peña DA;Rubiano K;Gómez-Hincapie J;Martínez NL;Lopez-Perez M;Castellanos A;Céspedes N;Palacios R;Oñate JM;Herrera S
通讯作者：
Herrera S
影响因子：
3.7
作者：
Bergmann-Leitner, Elke S.;Mease, Ryan M.;Angov, Evelina
通讯作者：
Angov, Evelina
影响因子：
5.5
作者：
Bell, Brian A.;Wood, James F.;Yadava, Anjali
通讯作者：
Yadava, Anjali
DOI：
10.4269/ajtmh.2002.66.641
发表时间：
2002-06-01
影响因子：
3.3
作者：
Alves, FP;Durlacher, RR;Camargo, EP
通讯作者：
Camargo, EP
影响因子：
3.1
作者：
Atcheson E;Bauza K;Salman AM;Alves E;Blight J;Viveros-Sandoval ME;Janse CJ;Khan SM;Hill AVS;Reyes-Sandoval A
通讯作者：
Reyes-Sandoval A