Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy
Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy
复制标题
甘油三酯降低和血清脂蛋白脂肪酶水平升高与腹腔镜袖状胃切除术后高密度脂蛋白胆固醇水平升高相关
作者：
Ohira M;Watanabe Y;Yamaguchi T;Onda H;Yamaoka S;Abe K;Nakamura S;Tanaka S;Kawagoe N;Nabekura T;Oshiro T;Nagayama D;Tatsuno I;Saiki A
简介腹腔镜袖状胃切除术 (LSG) 显着增加肝素前血清中的高密度脂蛋白胆固醇 (HDL-C) 和脂蛋白脂肪酶 (LPL)（肝素前 LPL 水平）。 LPL 是血清甘油三酯 (TG) 和 HDL-C 生成的调节剂；这可能是LSG后HDL-C升高的机制。本研究旨在通过研究LSG后血清HDL-C水平的变化与LPL之间的关系来阐明HDL-C水平升高的机制。方法我们回顾性分析了104例接受LSG的肥胖患者，并随访12个月。我们分析了LSG后血清HDL-C水平的变化与各种临床参数之间的关系。结果LSG后患者的BMI和血清TG水平显着下降。相反，LSG 后 HDL-C 水平和肝素前 LPL 水平显着升高。简单线性回归显示，HDL-C 水平的变化与总体重减轻百分比、TG 水平变化、腹部脂肪面积和肝素前 LPL 水平显着相关。此外，多元回归模型显示，TG 水平降低和肝素前 LPL 水平升高与 LSG 后 HDL-C 水平升高相关。讨论/结论这些结果表明，TG 水平降低和 LPL 升高是 LSG 后 HDL-C 水平升高的机制。
IntroductionLaparoscopic sleeve gastrectomy (LSG) significantly increases high-density lipoprotein cholesterol (HDL-C) and lipoprotein lipase (LPL) in pre-heparin serum (pre-heparin LPL levels). LPL is a regulator of serum triglyceride (TG) and HDL-C production; this may be the mechanism for HDL-C increase after LSG. This study aimed to elucidate the mechanism of increase in HDL-C levels by examining the relationship between changes in serum HDL-C levels and LPL after LSG.MethodsWe retrospectively reviewed 104 obese patients, who underwent LSG and were followed up for 12 months. We analyzed the relationship between changes in serum HDL-C levels and various clinical parameters after LSG.ResultsA significant decrease was observed in the patients’ BMI and serum TG levels after LSG. Conversely, HDL-C levels and pre-heparin LPL levels were significantly increased after LSG. Simple linear regression showed that changes in HDL-C levels were significantly correlated with total weight loss percentage, change in TG levels, abdominal fat areas, and pre-heparin LPL levels. Additionally, the multiple regression model revealed that a decrease in TG levels and an increase in pre-heparin LPL levels were correlated with increased HDL-C levels after LSG.Discussion/ConclusionThese results show that a decrease in TG levels and an increase in LPL are mechanisms for increased HDL-C levels after LSG.
登录
查看更多内容
DOI：
10.1056/nejmoa1506699
发表时间：
2016-01-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inge TH;Courcoulas AP;Jenkins TM;Michalsky MP;Helmrath MA;Brandt ML;Harmon CM;Zeller MH;Chen MK;Xanthakos SA;Horlick M;Buncher CR;Teen-LABS Consortium
通讯作者：
Teen-LABS Consortium
吡格列酮可降低 2 型糖尿病患者的血浆血管紧张素 II 浓度。
影响因子：
4.4
作者：
A. Saiki;M. Ohira;K. Endo;Nobukiyo Koide;T. Oyama;T. Murano;Y. Miyashita;K. Shirai
通讯作者：
K. Shirai
高甘油三酯血症患者血浆高密度脂蛋白胆固醇的决定因素。
DOI：
10.1161/01.atv.17.1.56
发表时间：
1997
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Tato,F;Vega,GL;Grundy,SM
通讯作者：
Grundy,SM
影响因子：
2.9
作者：
Dogan, Serdar;Aslan, Ibrahim;Aslan, Mutay
通讯作者：
Aslan, Mutay
影响因子：
8.7
作者：
TORNVALL, P;OLIVECRONA, G;OLIVECRONA, T
通讯作者：
OLIVECRONA, T