PPARγ and stress: implications for aging.
PPARγ and stress: implications for aging.
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DOI：
10.1016/j.exger.2012.08.011
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发表时间：
2013-07
影响因子：
3.9
通讯作者：
Ryan, Karen K.
中科院分区：
文献类型：
--
作者：
Ulrich-Lai, Yvonne M.;Ryan, Karen K.
复杂的相互作用将心理压力和衰老联系在一起——压力通常会促进衰老过程，相反，衰老会导致压力失调。压力和衰老对大脑的影响非常相似。两者都诱导神经炎症并改变神经元的代谢和活动，这在不同程度上与压力和衰老病理的发展有因果关系。因此，由压力或衰老引起的一种或多种大脑紊乱可能会导致另一种功能障碍的发展。值得注意的是，过氧化物酶体增殖体激活受体γ (PPARγ)在调节应激和衰老的大脑区域（如海马）中表达，并可以预防衰老和应激对大脑的影响。此外，PPARγ激动剂本身可减少生理应激反应。因此，PPARγ可能代表了脑老化和压力之间的关键机制联系，可能具有预防和治疗与年龄相关的认知和情绪障碍的治疗潜力。
Complex interactions link psychological stress and aging - stress generally promotes aging processes, and conversely, aging can contribute to stress dysregulation. Stress and aging have remarkably similar effects on brain. Both induce neuroinflammation and alter neuronal metabolism and activity, which to varying extents are causally-linked to the development of stress and aging pathology. As such, induction of one or more of these brain disturbances by either stress or aging could predispose for the development of dysfunction in the other. Notably, peroxisome proliferator-activated receptor γ (PPARγ) is expressed in brain regions that regulate both stress and aging (e.g., hippocampus) and can act to prevent the consequences of aging and stress on the brain. In addition, PPARγ agonists reduce the physiological stress response itself. Thus, PPARγ may represent a critical mechanistic link between brain aging and stress that could hold therapeutic potential for the prevention and treatment of age-related cognitive and mood disorders.
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