HPA axis responsiveness to stress: implications for healthy aging.
HPA axis responsiveness to stress: implications for healthy aging.
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DOI：
10.1016/j.exger.2010.08.023
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发表时间：
2011-02
影响因子：
3.9
通讯作者：
Aguilera, Greti
中科院分区：
文献类型：
--
作者：
Aguilera, Greti
关键词：
介导应激适应的主要神经内分泌反应是下丘脑 - 垂体 - 肾上腺轴的激活，下丘脑室旁核小细胞神经元分泌促肾上腺皮质激素释放激素（CRH）和血管加压素（VP）受到刺激，从而刺激垂体促肾上腺皮质激素（ACTH）的分泌，并使肾上腺皮质糖皮质激素的分泌增加。糖皮质激素及其下丘脑调节因子在基础状态下的产生以及在应激期间的短暂增加对神经元可塑性和正常脑功能至关重要。虽然下丘脑 - 垂体 - 肾上腺（HPA）轴的激活对应激期间的生存至关重要，但长期暴露于应激激素可能导致心理、代谢和免疫方面的改变。因此，迅速终止应激反应对于防止不适当水平的CRH和糖皮质激素的负面影响至关重要。本综述阐述了HPA轴活动的调节，重点强调了CRH转录终止的机制，这是该过程中的关键步骤。此外，还将讨论糖皮质激素、CRH和VP影响衰老过程的作用。
The major neuroendocrine response mediating stress adaptation is activation of the hypothalamic pituitary adrenal axis, with stimulation of corticotropin releasing hormone (CRH) and vasopressin (VP) from parvocellular neurons of the hypothalamic paraventricular nucleus, leading to stimulation of pituitary ACTH secretion and increases in glucocorticoid secretion from the adrenal cortex. Basal production and transient increases during stress of glucocorticoids and its hypothalamic regulators are essential for neuronal plasticity and normal brain function. While activation of the HPA axis is essential for survival during stress, chronic exposure to stress hormones can predispose to psychological, metabolic and immune alterations. Thus, prompt termination of the stress response is essential to prevent negative effects of inappropriate levels of CRH and glucocorticoids. This review addresses the regulation of HPA axis activity with emphasis on the mechanisms of termination of CRH transcription, which is a critical step in this process. In addition, the actions by which glucocorticoids, CRH and VP can affect the aging process will be discussed.
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DOI：
10.1152/ajpregu.1997.273.5.r1764
发表时间：
1997-11-01
影响因子：
2.8
作者：
Cai, AH;Scarbrough, K;Wise, PM
通讯作者：
Wise, PM
DOI：
10.1016/0169-328x(95)00304-b
发表时间：
1996-04-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Ceccatelli, S;Calza, L;Giardino, L
通讯作者：
Giardino, L
影响因子：
5.3
作者：
Chen, Jun;Volpi, Simona;Aguilera, Greti
通讯作者：
Aguilera, Greti
影响因子：
5.2
作者：
Chen, Jun;Young, Sharla;Subburaju, Sivan;Sheppard, Jack;Kiss, Alexander;Atkinson, Helen;Wood, Susan;Lightman, Stafford;Gal, Claudine Serradeil-Le;Aguilera, Greti
通讯作者：
Aguilera, Greti
影响因子：
4.8
作者：
Dermitzaki, E;Tsatsanis, C;Margioris, AN
通讯作者：
Margioris, AN