Effect of Infant RSV Infection on Memory T Cell Responses at Age 2-3 Years.
Effect of Infant RSV Infection on Memory T Cell Responses at Age 2-3 Years.
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DOI：
10.3389/fimmu.2022.826666
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发表时间：
2022
影响因子：
7.3
通讯作者：
Anderson LJ
中科院分区：
文献类型：
--
作者：
Chirkova T;Rosas-Salazar C;Gebretsadik T;Jadhao SJ;Chappell JD;Peebles RS Jr;Dupont WD;Newcomb DC;Berdnikovs S;Gergen PJ;Hartert TV;Anderson LJ
目前尚不清楚婴儿时期的RSV感染是否会改变随后的RSV免疫反应。在一组健康的足月儿童的嵌套队列中，收集了2-3岁的外周血单核细胞(PBMC)，以检查在婴儿期(第一年)感染过RSV的儿童与在婴儿期未感染RSV的儿童之间的RSV记忆T细胞反应。婴儿是否存在RSV感染通过RSV分子检测和血清学检测相结合来确定。检测RSV刺激的PBMCs的记忆反应。与第一年未感染RSV的儿童相比，在婴儿期感染RSV的儿童在2-3岁时对大多数被测试的类型1的RSV和许多记忆T细胞亚群的类型17标记的体外刺激的记忆T细胞反应较低。婴儿期呼吸道合胞病毒感染对记忆T细胞反应有长期影响。这是第一项研究表明，无论感染的严重程度如何，婴儿时期的RSV感染都有可能对免疫记忆产生长期影响。我们的结果提示了一种可能的机制，通过这种机制，婴儿RSV感染可能导致随后儿童呼吸道病毒发病的更大风险，这一发现也与疫苗开发相关。
It is unknown whether RSV infection in infancy alters subsequent RSV immune responses. In a nested cohort of healthy, term children, peripheral blood mononuclear cells (PBMCs) were collected at ages 2-3 years to examine RSV memory T cell responses among children previously RSV infected during infancy (first year of life) compared to those RSV-uninfected during infancy. The presence vs. absence of infant RSV infection was determined through a combination of RSV molecular and serologic testing. Memory responses were measured in RSV stimulated PBMCs. Compared to children not infected with RSV during the first year of life, children infected with RSV during infancy had lower memory T cell responses at ages 2-3 years to in vitro stimulation with RSV for most tested type-1 and type-17 markers for a number of memory T cell subsets. RSV infection in infancy has long-term effects on memory T cell responses. This is the first study to show the potential for RSV infection in infancy to have long-term effects on the immune memory irrespective of the severity of the infection. Our results suggest a possible mechanism through which infant RSV infection may result in greater risk of subsequent childhood respiratory viral morbidity, findings also relevant to vaccine development.
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DOI：
10.4049/jimmunol.1800396
发表时间：
2018-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Connors TJ;Baird JS;Yopes MC;Zens KD;Pethe K;Ravindranath TM;Ho SH;Farber DL
通讯作者：
Farber DL
DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P
影响因子：
5.4
作者：
Chirkova, Tatiana;Boyoglu-Barnum, Seyhan;Anderson, Larry J.
通讯作者：
Anderson, Larry J.
DOI：
10.1164/rccm.201903-0588oc
发表时间：
2020-02-01
影响因子：
24.7
作者：
Siefker, David T.;Luan Vu;Cormier, Stephania A.
通讯作者：
Cormier, Stephania A.
DOI：
10.1016/s0140-6736(17)30938-8
发表时间：
2017-09-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
Shi T;McAllister DA;O'Brien KL;Simoes EAF;Madhi SA;Gessner BD;Polack FP;Balsells E;Acacio S;Aguayo C;Alassani I;Ali A;Antonio M;Awasthi S;Awori JO;Azziz-Baumgartner E;Baggett HC;Baillie VL;Balmaseda A;Barahona A;Basnet S;Bassat Q;Basualdo W;Bigogo G;Bont L;Breiman RF;Brooks WA;Broor S;Bruce N;Bruden D;Buchy P;Campbell S;Carosone-Link P;Chadha M;Chipeta J;Chou M;Clara W;Cohen C;de Cuellar E;Dang DA;Dash-Yandag B;Deloria-Knoll M;Dherani M;Eap T;Ebruke BE;Echavarria M;de Freitas Lázaro Emediato CC;Fasce RA;Feikin DR;Feng L;Gentile A;Gordon A;Goswami D;Goyet S;Groome M;Halasa N;Hirve S;Homaira N;Howie SRC;Jara J;Jroundi I;Kartasasmita CB;Khuri-Bulos N;Kotloff KL;Krishnan A;Libster R;Lopez O;Lucero MG;Lucion F;Lupisan SP;Marcone DN;McCracken JP;Mejia M;Moisi JC;Montgomery JM;Moore DP;Moraleda C;Moyes J;Munywoki P;Mutyara K;Nicol MP;Nokes DJ;Nymadawa P;da Costa Oliveira MT;Oshitani H;Pandey N;Paranhos-Baccalà G;Phillips LN;Picot VS;Rahman M;Rakoto-Andrianarivelo M;Rasmussen ZA;Rath BA;Robinson A;Romero C;Russomando G;Salimi V;Sawatwong P;Scheltema N;Schweiger B;Scott JAG;Seidenberg P;Shen K;Singleton R;Sotomayor V;Strand TA;Sutanto A;Sylla M;Tapia MD;Thamthitiwat S;Thomas ED;Tokarz R;Turner C;Venter M;Waicharoen S;Wang J;Watthanaworawit W;Yoshida LM;Yu H;Zar HJ;Campbell H;Nair H;RSV Global Epidemiology Network
通讯作者：
RSV Global Epidemiology Network