Validating the accuracy of multispectral metal artifact suppressed diffusion-weighted imaging.
Validating the accuracy of multispectral metal artifact suppressed diffusion-weighted imaging.
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DOI：
10.1002/mp.15925
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发表时间：
2022-10
期刊：
影响因子：
3.8
通讯作者：
Tan, Ek T.
中科院分区：
文献类型：
--
作者：
Neri, John P.;Koff, Matthew F.;Koch, Kevin M.;Tan, Ek T.
扩散加权成像（DWI）提供了组织中随机水位移的定量测量，由表观扩散系数（ADC）计算。虽然DWI在中风和肿瘤应用中被广泛使用，但它是一种很有前途的工具，可用于绘制肌肉骨骼应用中的微结构变化，包括评估全髋关节置换术（THA）后滑膜反应。DWI在THA中的应用面临的一个主要挑战是与使用的传统回波平面成像（EPI）读数相关的显著伪影。多光谱成像（MSI）技术，包括多采集可变磁共振图像组合（MAVRIC），已被证明可以有效减少全关节置换术周围的金属敏感性伪影，从而提供临床有用的图像。最近，一种带有增强重建（PROPELLER） FSE采集的2D周期性旋转重叠平行线，结合了2D- mavric的扩散准备脉冲，以减轻失真和脱落现象。虽然已经对DWI-MAVRIC进行了一些初步评估，但DWI-MAVRIC的可重复性和关键参数（如光谱箱数）的影响尚不清楚。与传统扩散序列相比，评估DWI-MAVRIC的定量准确性。采用不同参考扩散系数（ADC=113 ~ 1123 μm2/s）的扩散模体。在两台1.5T MRI扫描仪上进行扫描。DWI-EPI和DWI-MAVRIC在轴位和冠状面均获得。采用离等心0 cm、左10 cm和右10 cm三个空间偏移量评价离等心定位效果。为了评估一天内和一天之间的重复性，在同一天和9个月的间隔在一台扫描仪上重复DWI-EPI和DWI-MAVRIC采集。为了评估扫描仪之间的重复性，比较了两台扫描仪之间的DWI-EPI和DWI-MAVRIC采集结果。采用梯度非线性校正（GNC）和不采用梯度非线性校正（GNC）分别生成ADC图。在计算值和参考ADC值之间进行线性回归、相关性和误差统计。生成Bland-Altman图来评估日内、日内和扫描仪间的重复性。与DWI-EPI （r= 1.00，斜率= 0.99 ~ 1.01）相比，DWI-MAVRIC与参考值具有良好的相关性，但线性度较低（r= 1.00，斜率=0.91 ~ 0.94）。在最低ADC值处观察到大于5%的ADC偏置，主要是在DWI-MAVRIC扫描中。ADC值不随DWI-MAVRIC参数变化。DWI-EPI采集的日内、日间和扫描仪间重复性分别为3.18 μm2/s、19.2 μm2/s和20.2 μm2/s。DWI-MAVRIC采集的日内、日间和扫描仪间重复性较差，分别为13.3 μm2/s、44.7 μm2/s和110 μm2/s。与左、右位置相比，等中心位置的ADC误差较低。梯度非线性校正后的中心位置、左位置和右位置的绝对误差分别降低0.31±0.89%、3.6±1.4%、0.65±2.4%。DWI-MAVRIC相对于参考值提供良好的线性和良好的日内和日内重复性。
Diffusion-weighted imaging (DWI) provides quantitative measurement of random water displacement in tissue as calculated by the apparent diffusion coefficient (ADC). While heavily utilized in stroke and oncology applications, DWI is a promising tool to map microstructural changes in musculoskeletal applications including evaluation of synovial reactions resulting from total hip arthroplasty (THA). One major challenge facing the application of DWI in THA is the significant artifacts related to the conventional echo-planar imaging (EPI) readout used. Multi-spectral imaging (MSI) techniques, including the multi-acquisition with variable resonance image combination (MAVRIC), have been shown to effectively reduce metallic susceptibility artifacts around total joint replacements to render clinically useful images. Recently, a 2D periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) FSE acquisition that incorporates a diffusion preparation pulse with 2D-MAVRIC has been developed to mitigate both distortion and dropout artifacts. While there have been some preliminary assessments of DWI-MAVRIC, the repeatability of DWI-MAVRIC and the effects of key parameters, such as the number of spectral bins, are unknown. To evaluate the quantitative accuracy of DWI-MAVRIC as compared to conventional diffusion sequences. A diffusion phantom with different reference diffusivities (ADC=113 to 1123 μm2/s) was used. Scans were performed on two 1.5T MRI scanners. DWI-EPI and DWI-MAVRIC were acquired in both the axial and coronal planes. Three spatial offsets (0 cm, 10 cm left and 10 cm right off iso-center) were used to evaluate effects of off-isocenter positioning. To assess intra-day and inter-day repeatability, DWI-EPI and DWI-MAVRIC acquisitions were repeated on one scanner at same-day and nine-month intervals. To assess inter-scanner repeatability, DWI-EPI and DWI-MAVRIC acquisitions were compared between two scanners. ADC maps were generated with and without gradient nonlinearity correction (GNC). Linear regression, correlation and error statistics were determined between calculated and reference ADC values. Bland-Altman plots were generated to evaluate intra-day, inter-day, and inter-scanner repeatability. DWI-MAVRIC had excellent correlation to reference values but at reduced linearity (r= 1.00, slope=0.91 to 0.94) as compared to DWI-EPI (r= 1.00, slope= 0.99 to 1.01). A greater than 5% ADC bias was observed at the lowest ADC values, predominantly in the DWI-MAVRIC scans. ADC values did not vary with DWI-MAVRIC parameters. DWI-EPI acquisitions had intra-day, inter-day, and inter-scanner repeatability of 3.18 μm2/s, 19.2 μm2/s and 20.2 μm2/s, respectively. DWI-MAVRIC acquisitions had inferior intra-day, inter-day, and inter-scanner repeatability of 13.3 μm2/s, 44.7 μm2/s, 110 μm2/s, respectively. Lower ADC errors were found at isocenter, as compared to the left and right positions. Gradient nonlinearity correction reduced the absolute error by 0.31 ± 0.89 %, 3.6 ± 1.4 %, 0.65 ± 2.4 % for the center, left, and right positions, respectively. DWI-MAVRIC provides good linearity with respect to reference values and good intra- and inter-day repeatability.
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