Computational modeling of synchronization process of the circadian timing system of mammals
Computational modeling of synchronization process of the circadian timing system of mammals
复制标题
哺乳动物昼夜节律系统同步过程的计算模型
DOI：
10.1007/s00422-009-0309-6
复制
发表时间：
2009
影响因子：
1.9
通讯作者：
C. Cortez
中科院分区：
文献类型：
--
作者：
F. R. G. Cardoso;F. Cruz;Dílson Silva;C. Cortez
本文提出了一种哺乳动物昼夜节律时态系统的模型，该模型将耦合振荡器的同步动力学与一组能够再现神经元体树突膜突触特征的方程联系起来。昼夜节律系统是以从外部和内部环境接收信息的方式组织的，其功能是以昼夜模式对生理和行为过程进行时序组织。哺乳动物的昼夜节律系统由一组结构组成，包括视交叉上核、膝间小叶和松果体。在视交叉上核，神经元群起着生物起搏器的作用，也就是所谓的生物主钟。通过使用Kuramoto模型进行数值模拟，模拟了生物起搏器的动力学行为。为此，我们使用了一组1000个长程耦合振子，它们分布在一个10×10×10×10的球面晶格上，并使用了一种新的方法来估计序参数，它表征了振子系统的同步程度。我们的模型已经能够产生与生理模式一致的频率响应，并再现了生物节律的两个基本特征：内源性生成和与明暗周期的同步。
This paper presents a model for the circadian temporization system of mammals which associates the synchronization dynamics of coupling oscillators to a set of equations able to reproduce the synaptic characteristics of somatodendritic membrane of neurons. The circadian timing system is organized in a way to receive information from the external and internal environments, and its function is the timing organization of physiological and behavioral processes in a circadian pattern. Circadian timing system in mammals is constituted by a group of structures which includes the suprachiasmatic nucleus, the intergeniculate leaflet and the pineal gland. In suprachiasmatic nucleus are found neuron groups working as a biological pacemaker—the so-called biological master clock. By means of numerical simulations using the Kuramoto model, we simulated the dynamics behavior of the biological pacemaker. For this we used a set of 1,000 coupled oscillators with long-range coupling, which were distributed on a 10 × 10 × 10 spherical lattice, and a new method to estimate the order parameter, which characterizes the degree of synchronization of oscillator system. Our model has been able to produce frequency responses in accordance with physiological patterns, and to reproduce two fundamental characteristics of biological rhythms: the endogenous generation and synchronization to the light–dark cycle.
DOI：
10.1073/pnas.89.12.5670
发表时间：
1992-06-15
影响因子：
11.1
作者：
MURTHY, VN;FETZ, EE
通讯作者：
FETZ, EE
影响因子：
--
作者：
MOOREEDE, MC
通讯作者：
MOOREEDE, MC
影响因子：
2.5
作者：
Jezzini, SH;Hill, AAV;Calabrese, RL
通讯作者：
Calabrese, RL