Transcriptional profiling of vaccine-induced immune responses in humans and non-human primates.
Transcriptional profiling of vaccine-induced immune responses in humans and non-human primates.
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DOI：
10.1111/j.1751-7915.2011.00317.x
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发表时间：
2012-03
影响因子：
5.7
通讯作者：
ter Meulen J
中科院分区：
文献类型：
--
作者：
Wang IM;Bett AJ;Cristescu R;Loboda A;ter Meulen J
迫切需要预测疫苗免疫原性、有效性和安全性的临床前和临床生物标志物，以降低与疫苗开发相关的风险和成本。非人类灵长类动物和人类免疫分析研究的结果清楚地表明，(i) 免疫记忆的类型和持续时间很大程度上取决于先天免疫信号的强度和复杂性，以及 (ii) 可以针对特定疫苗识别高度预测 B 细胞和 T 细胞反应的遗传特征。对于具有相似成分的疫苗，例如减毒活病毒疫苗，这些特征具有共同的模式。在一些实验性挑战研究中已经确定了预测疫苗功效的特征。本综述旨在概述当前有关人类免疫分析研究的文献，并介绍我们自己的一些关于非人类灵长类动物的许可和实验疫苗分析的数据。
There is an urgent need for pre‐clinical and clinical biomarkers predictive of vaccine immunogenicity, efficacy and safety to reduce the risks and costs associated with vaccine development. Results emerging from immunoprofiling studies in non‐human primates and humans demonstrate clearly that (i) type and duration of immune memory are largely determined by the magnitude and complexity of the innate immune signals and (ii) genetic signatures highly predictive of B‐cell and T‐cell responses can be identified for specific vaccines. For vaccines with similar composition, e.g. live attenuated viral vaccines, these signatures share common patterns. Signatures predictive of vaccine efficacy have been identified in a few experimental challenge studies. This review aims to give an overview of the current literature on immunoprofiling studies in humans and also presents some of our own data on profiling of licensed and experimental vaccines in non‐human primates.
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影响因子：
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通讯作者：
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