The Toll immune signaling pathway control conserved anti-dengue defenses across diverse Ae. aegypti strains and against multiple dengue virus serotypes.
The Toll immune signaling pathway control conserved anti-dengue defenses across diverse Ae. aegypti strains and against multiple dengue virus serotypes.
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DOI：
10.1016/j.dci.2010.01.006
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发表时间：
2010-06
影响因子：
2.9
通讯作者：
Dimopoulos, George
中科院分区：
文献类型：
--
作者：
Ramirez, Jose L.;Dimopoulos, George
登革病毒已成为影响当今世界的最重要的虫媒病毒病原体之一。该病毒通过埃及伊蚊和埃及伊蚊在人类之间传播。白纹伊蚊像其他媒介传播的病原体一样，这种病毒在蚊子媒介中遇到先天免疫防御，限制感染。我们之前已经证明了Toll途径在感染后7天参与抗登革热防御。在本研究中，我们研究了这种免疫信号通路在实验室和野外来源的蚊子株感染早期阶段对不同登革热病毒血清型的活性。我们的研究证实了Toll途径在感染性血餐后3天的抗登革热防御谱中的重要性，此时新的病毒体从中肠释放，用于传播和感染其他蚊子组织。此外，这些免疫防御在不同的Ae之间是保守的。埃及菌株，并可对广泛的登革热病毒血清型起作用。
Dengue virus has become one of the most important arboviral pathogens affecting the world today. The virus is transmitted among humans by the mosquitoes Aedes aegypti and Ae. albopictus. Like other vector-borne pathogens, this virus encounters innate immune defenses within the mosquito vector that limit infection. We have previously demonstrated the involvement of the Toll pathway in the anti-dengue defense at 7 days after infection. In the present study, we have investigated the activity of this immune signaling pathway against different dengue virus serotypes at the early stages of infection in laboratory and field-derived mosquito strains. Our studies corroborate the importance of the Toll pathway in the anti-dengue defense repertoire at 3 days after an infectious blood meal, when new virions are released from the midgut for dissemination and infection of other mosquito tissues. These immune defenses are furthermore conserved among different Ae. aegypti strains and can act against a broad range of dengue virus serotypes.
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