Enhancing adult neurogenesis promotes contextual fear memory discrimination and activation of hippocampal-dorsolateral septal circuits.
Enhancing adult neurogenesis promotes contextual fear memory discrimination and activation of hippocampal-dorsolateral septal circuits.
复制标题
增强成人神经发生促进情境恐惧记忆辨别和海马背外侧间隔回路的激活。
DOI：
10.1016/j.bbr.2020.112917
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发表时间：
2021-02-05
影响因子：
2.7
通讯作者：
Sahay A
中科院分区：
文献类型：
--
作者：
Besnard A;Sahay A
海马神经回路通过成年出生的齿状颗粒细胞（DGC）的整合而不断改变。先前的工作已经表明，增强成人海马神经发生减少了类似背景的集合之间的干扰或重叠或冲突，并促进了从类似的中性背景中区分与休克相关的背景。然而，成年出生的神经元的整合增强对海马网络活动或下游电路，如介导防御行为反应的背外侧隔的影响知之甚少。在这里，我们首先重复了我们的发现，即成年出生的齿状颗粒细胞（8周及以下）的遗传扩张促进了背景恐惧歧视。我们发现，增强上下文的恐惧歧视与更大的c-Fos表达离散海马子字段沿着近端-远端和背腹轴。背外侧隔的检查显示，生长抑素表达神经元的激活增加，这与最近将这些细胞作为防御行为的校准物的表征一致。总之，这些发现开始揭示了遗传增强成年海马神经发生如何影响海马-背外侧隔回路的活动。
Hippocampal circuitry is continuously modified by integration of adult-born dentate granule cells (DGCs). Prior work has shown that enhancing adult hippocampal neurogenesis decreases interference or overlap or conflict between ensembles of similar contexts and promotes discrimination of a shock-associated context from a similar, neutral context. However, the impact of enhanced integration of adult-born neurons on hippocampal network activity or downstream circuits such as the dorsolateral septum that mediate defensive behavioral responses is poorly understood. Here, we first replicated our finding that genetic expansion of the population of adult-born dentate granule cells (8 weeks and younger) promotes contextual fear discrimination. We found that enhanced contextual fear discrimination is associated with greater c-Fos expression in discrete hippocampal subfields along the proximo-distal and dorsoventral axis. Examination of the dorsolateral septum revealed an increase in activation of somatostatin expressing neurons consistent with recent characterization of these cells as calibrators of defensive behavior. Together, these findings begin to shed light on how genetically enhancing adult hippocampal neurogenesis affects activity of hippocampal-dorsolateral septal circuits.
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影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
2.7
作者：
Cullen, Patrick K.;Gilman, T. Lee;Jasnow, Aaron M.
通讯作者：
Jasnow, Aaron M.
影响因子：
16.6
作者：
Berdugo-Vega, Gabriel;Arias-Gil, Gonzalo;Calegari, Federico
通讯作者：
Calegari, Federico
影响因子：
25
作者：
Besnard, Antoine;Gao, Yuan;Sahay, Amar
通讯作者：
Sahay, Amar
影响因子：
3.1
作者：
Antoine, Besnard;Serge, Laroche;Jocelyne, Caboche
通讯作者：
Jocelyne, Caboche