Innate immune responses against the fungal pathogen Candida auris.

Innate immune responses against the fungal pathogen Candida auris.
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针对真菌病原体耳念珠菌的先天免疫反应

DOI:
10.1038/s41467-022-31201-x
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发表时间:
2022-06-21
影响因子:
16.6
通讯作者:
--
中科院分区:
综合性期刊1区
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--
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耳念珠菌是一种多药耐药的人类真菌病原体负责医院爆发世界各地。虽然相当大的进展增加了我们对C的生物学和临床方面的理解。耳,它与宿主免疫系统的相互作用现在才开始深入研究。在这里,我们比较了C。耳BJCA 001和白色念珠菌SC 5314的体外和体内试验。结果表明,C. auris BJCA 001的免疫炎症反应较C.白色念珠菌SC5314,这种差异反应与细胞壁的结构特征相关。
Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects of C. auris, its interaction with the host immune system is only now beginning to be investigated in-depth. Here, we compare the innate immune responses induced by C. auris BJCA001 and Candida albicans SC5314 in vitro and in vivo. Our results indicate that C. auris BJCA001 appears to be less immunoinflammatory than C. albicans SC5314, and this differential response correlates with structural features of the cell wall.
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