Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals.

Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals.
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DOI:
10.1038/nn.3104
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发表时间:
2012-06
影响因子:
25
通讯作者:
--
中科院分区:
医学1区
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--
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竞争性暴露导致果蝇雄性延长交配。较长的交配持续时间(LMD)可能会提高繁殖成功率,但其潜在的机制目前尚不清楚。在这里,我们报告说,LMD是上下文相关的,可以通过视觉刺激单独诱导。我们进一步表明,LMD涉及重要的视觉记忆的神经回路,包括中央神经元的椭圆体,但不是蘑菇体或扇形体,并可能依赖于竞争对手的曝光记忆持续几个小时。LMD受到学习和记忆突变体的影响。LMD依赖于生物钟基因的无时间性和周期性,而不是时钟或周期,并在许多疾病条件下持续存在。此外,LMD严重依赖于色素分散因子(PDF)神经元的子集,而不是整个昼夜神经回路。因此,我们的研究描绘了LMD的分子和细胞基础的一部分-由视觉线索引起的可塑性社会行为。
Rival exposure causes Drosophila melanogaster males to prolong mating. Longer-Mating-Duration (LMD) may enhance reproductive success, but its underlying mechanism is currently unknown. Here we report that LMD is context-dependent and can be induced solely via visual stimuli. We further show that LMD involves neural circuits important for visual memory, including central neurons in the ellipsoid body but not the mushroom bodies or the fan-shaped bodies, and may rely on the rival exposure memory lasting several hours. LMD is affected by a subset of learning and memory mutants. LMD depends on the circadian clock genes timeless and period but not Clock or cycle, and persists in many arrhythmic conditions. Moreover, LMD critically depends on a subset of pigment dispersing factor (PDF) neurons rather than the entire circadian neural circuit. Our study thus delineates parts of the molecular and cellular basis for LMD – a plastic social behavior elicited by visual cues.
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