Lymph node status and its impact on the prognosis of left-sided and right-sided colon cancer: A SEER population-based study.
Lymph node status and its impact on the prognosis of left-sided and right-sided colon cancer: A SEER population-based study.
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淋巴结状态及其对左侧和右侧结肠癌预后的影响：一项基于 SEER 人群的研究。
DOI：
10.1002/cam4.4357
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发表时间：
2021-12
期刊：
影响因子：
4
通讯作者：
Chu X
中科院分区：
文献类型：
--
作者：
Huang Y;Ji L;Zhu J;Mao X;Sheng S;Hao S;Xiang D;Guo J;Fu G;Huang M;Lei Z;Chu X
左侧和右侧结肠癌患者的结局存在显着差异。侧面结肠癌患者确定该因素对预后的影响。
我们的数据是从监视，流行病学（SEER）数据库中获得的，我们使用卡方检验来分析X-tile计划曲线用于分析提示，并进行多元COX回归模型，以识别与生存相关的独立因素。预测患者的总体存活率，Harrell的C索引和校准图用于验证列图。
该研究包括189,941例无转移的结肠癌患者（剩余69,885，右12056），在2004年至2015年之间。有更多的患者淋巴结的患者有更多的淋巴结。关于死亡的风险。淋巴结状态是预测直接结肠患者结果的主要因素。
在没有转移的情况下，淋巴结癌患者之间的淋巴结状态对预测预后的影响显着不同。
淋巴结状态对预测预后的影响在左侧和右侧结肠癌患者之间显着不同。
Some significant differences exist between the outcomes of left‐ and right‐sided colon cancer patients. The presence of nodal metastases is a critical prognostic factor, especially in the absence of distant metastasis. Our research studied the lymph nodes status of left‐ and right‐sided colon cancer patients to determine the influence of this factor on prognosis. Our data were obtained from the Surveillance, Epidemiology and End Results (SEER) database. We used the chi‐square test to analyze the clinicopathological characteristics. The X‐tile program was adopted to acquire optimal cutoff points of lymph node index. Kaplan–Meier curves were used to analyze prognosis and multivariate Cox regression models were performed to identify the independent factors associated with survival. Nomograms were built to predict the overall survival of patients, Harrell's C‐index and calibration plots were used to validate the nomograms. The study included 189,941 patients with colon cancer without metastasis (left 69,885, right 120,056) between 2004 and 2015. There are more patients with adequate examined lymph nodes in right‐sided. Lymph node status in patients with right colon cancer has a more significant impact on the risk of death. LODDS (C‐index: 0.583; AIC: 6875.4) was used to assess lymph node status. The nomograms showed that lymph node status was the main factor to predict the outcome in right‐sided colon patients. The influence of lymph node status on predicting prognosis is significantly different between patients with left and right colon cancer without metastasis. The tumor site needs to be considered when lymph node status is used to assess the outcome of patients. The effect of lymph node status on predicting prognosis differed significantly between left‐sided and right‐sided colon cancer patients. The tumor site needs to be considered when lymph node status is used to assess the outcome of patients.
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影响因子：
4.5
作者：
Mangone L;Pinto C;Mancuso P;Ottone M;Bisceglia I;Chiaranda G;Michiara M;Vicentini M;Carrozzi G;Ferretti S;Falcini F;Hassan C;Rossi PG
通讯作者：
Rossi PG
影响因子：
28.4
作者：
Petrelli, Fausto;Tomasello, Gianluca;Barni, Sandro
通讯作者：
Barni, Sandro
影响因子：
3.9
作者：
Pan, Xingxi;Yang, Wen;Li, Hui
通讯作者：
Li, Hui
预测同步结直肠肝局限性转移的总体生存率和癌症特异性生存率的列线图
影响因子：
3.9
作者：
Li Y;Liu W;Zhao L;Güngör C;Xu Y;Song X;Wang D;Zhou Z;Zhou Y;Li C;Pei Q;Tan F;Pei H
通讯作者：
Pei H
DOI：
10.1016/s1470-2045(14)71116-7
发表时间：
2015-04
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Balachandran VP;Gonen M;Smith JJ;DeMatteo RP
通讯作者：
DeMatteo RP