Substance P immunoreactive nerves in airways from asthmatics and nonasthmatics.
Substance P immunoreactive nerves in airways from asthmatics and nonasthmatics.
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哮喘患者和非哮喘患者气道中的 P 物质免疫反应神经。
DOI：
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发表时间：
1991
影响因子：
24.3
通讯作者：
A. Woolcock
中科院分区：
文献类型：
--
作者：
S. Ollerenshaw;D. Jarvis;C. Sullivan;A. Woolcock
P物质位于人肺中为平滑肌、血管和腺体供血的神经，可能在哮喘的病理生理学中发挥重要作用。我们使用亲和素生物素过氧化物酶免疫染色技术进行了形态学研究，检查患有和不患有哮喘的受试者的气道壁切片中是否存在 P 物质免疫反应性神经纤维。通过尸检、肺叶切除和支气管镜检查获得200微米至12毫米的气道。对尸检时收集的三名哮喘受试者和三名非哮喘受试者的 3 毫米直径气道以及八名哮喘受试者和 13 名非哮喘受试者的 10 毫米直径气道活检进行定量形态学分析。与非哮喘受试者的气道相比，哮喘受试者气道中 P 物质免疫反应性神经纤维的数量和长度均有所增加。在固有层和周围的血管和腺体中发现了纤维。纤维通常被视为束而不是单纤维。正常受试者和慢性气流受限（CAL）受试者之间 P 物质神经的数量没有差异。哮喘和非哮喘受试者之间 P 物质免疫反应神经的数量、长度和形态特征存在显着差异。
Substance P has been localized to nerves supplying smooth muscle, blood vessels and glands in the human lung and may play a major role in the pathophysiology of asthma. We performed a morphological study, using the avidin biotin peroxidase immunostaining technique, to examine sections of airway wall from subjects with and without asthma for the presence of substance P immunoreactive nerve fibres. Airways of 200 microns-12 mm were obtained from autopsy, lobectomy and bronchoscopy. Quantitative morphological analysis was performed on 3 mm diameter airways from three asthmatic and three nonasthmatic subjects collected at autopsy, and on biopsies of 10 mm diameter airways from eight asthmatic and thirteen nonasthematic subjects. There was an increase in both the number and the length of substance P immunoreactive nerve fibres, in airways from subjects with asthma when compared with airways from subjects without asthma. Fibres were found in the lamina propria and surrounding vessels and glands. The fibres were commonly seen as bundles rather than as single fibres. There was no difference in the number of substance P nerves between normal subjects and subjects with chronic airflow limitation (CAL). The difference in the number, length and morphological characteristics of the substance P immunoreactive nerves between asthmatic and nonasthmatic subjects were striking.
肺部炎症中白细胞 P 物质受体依赖性反应。
DOI：
10.1164/ajrccm/136.6_pt_2.s39
发表时间：
1987
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Payan,DG;Goetzl,EJ
通讯作者：
Goetzl,EJ
脑啡肽酶抑制剂可增强哺乳动物速激肽诱导的雪貂气管收缩。
DOI：
--
发表时间：
1987
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Sekizawa,K;Tamaoki,J;Graf,PD;Basbaum,CB;Borson,DB;Nadel,JA
通讯作者：
Nadel,JA
脑啡肽酶抑制剂可增强 P 物质和电诱导的雪貂气管收缩。
DOI：
10.1152/jappl.1987.63.4.1401
发表时间：
1987
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Sekizawa,K;Tamaoki,J;Nadel,JA;Borson,DB
通讯作者：
Borson,DB