Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure.
Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure.
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慢性心力衰竭中压力感受器和迷走神经传入输入对心脏交感传入反射和交感活动的抑制
DOI：
10.1371/journal.pone.0025784
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Zhu GQ
中科院分区：
文献类型：
--
作者：
Gan XB;Duan YC;Xiong XQ;Li P;Cui BP;Gao XY;Zhu GQ
背景：慢性心力衰竭(CHF)大鼠心脏交感传入反射(CSAR)参与交感神经兴奋，室旁核(PVN)血管紧张素II(Ang II)增强CSAR。本研究旨在确定心衰大鼠(INT)是否存在这种情况，以及心脏和压力感受器传入对CHF大鼠CSAR和交感神经活动的影响。方法/主要研究结果：假手术(Sham)组和冠脉结扎组(CHF)大鼠分别行BD+VT、VT、去交感神经(CSD)或INT。在麻醉状态下，记录肾交感神经活动(RSNA)和平均动脉压(MAP)，并通过心外膜应用辣椒素的RSNA和MAP反应来评价CSAR。BD+VT、VT或INT均能增强CHF大鼠的CSAR或PVN内RSNA、MAP和CSAR对Ang II的反应。VT或BD+VT均可增强Sham和CHF大鼠的CSAR和对Ang II的CSAR反应。CSD可逆转辣椒素诱导的Sham和CHF大鼠的RSNA和MAP变化以及对Ang II的CSAR反应，并降低CHF大鼠仅对Ang II的RSNA和MAP反应。结论正常CHF大鼠室旁核对Ang II的CSAR和CSAR反应增强。压力感受器和迷走神经传入活动抑制完整Sham和CHF大鼠的CSAR和CSAR对Ang II的反应。
Background Cardiac sympathetic afferent reflex (CSAR) contributes to sympathetic activation and angiotensin II (Ang II) in paraventricular nucleus (PVN) augments the CSAR in vagotomized (VT) and baroreceptor denervated (BD) rats with chronic heart failure (CHF). This study was designed to determine whether it is true in intact (INT) rats with CHF and to determine the effects of cardiac and baroreceptor afferents on the CSAR and sympathetic activity in CHF. Methodology/Principal Findings Sham-operated (Sham) or coronary ligation-induced CHF rats were respectively subjected to BD+VT, VT, cardiac sympathetic denervation (CSD) or INT. Under anesthesia, renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded, and the CSAR was evaluated by the RSNA and MAP responses to epicardial application of capsaicin. Either CSAR or the responses of RSNA, MAP and CSAR to Ang II in PVN were enhanced in CHF rats treated with BD+VT, VT or INT. Treatment with VT or BD+VT potentiated the CSAR and the CSAR responses to Ang II in both Sham and CHF rats. Treatment with CSD reversed the capsaicin-induced RSNA and MAP changes and the CSAR responses to Ang II in both Sham and CHF rats, and reduced the RSNA and MAP responses to Ang II only in CHF rats. Conclusions The CSAR and the CSAR responses to Ang II in PVN are enhanced in intact CHF rats. Baroreceptor and vagal afferent activities inhibit CSAR and the CSAR responses to Ang II in intact Sham and CHF rats.
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影响因子：
3.7
作者：
Dans AL;Teo K;Gao P;Chen JH;Jae-Hyung K;Yusoff K;Chaithiraphan S;Zhu J;Lisheng L;Yusuf S;Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial Investigators
通讯作者：
Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial Investigators
影响因子：
8.3
作者：
Malliani, A;Montano, N
通讯作者：
Montano, N
DOI：
10.1152/ajpheart.00958.2008
发表时间：
2008-12-01
影响因子：
4.8
作者：
Yoshimoto, Misa;Wehrwein, Erica A.;Osborn, John W.
通讯作者：
Osborn, John W.
室旁核中的活性氧介导慢性心力衰竭大鼠的心脏交感传入反射
影响因子：
18.2
作者：
Han, Ying;Shi, Zhen;Zhu, Guo-Qing
通讯作者：
Zhu, Guo-Qing
影响因子：
3.3
作者：
Gao, Lie;Pan, Yan-Xia;Wang, Wei
通讯作者：
Wang, Wei