Alterations in the Neuronal Cytoskeleton in Alzheimer Disease
Alterations in the Neuronal Cytoskeleton in Alzheimer Disease
复制标题
阿尔茨海默病神经元细胞骨架的改变
DOI：
10.1007/978-1-4613-1657-2
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
George Perry
中科院分区：
文献类型：
--
作者：
George Perry
Mark Ellisman 1*，Rama Ranganathan*，Thomas Deerinck*，Stephen Young*，Robert Terry和Suzanne Mirra2*神经细胞学神经科学实验室，加州大学SD分校，La Jolla，行政医学中心和医学，亚特兰大，GA 30033 M008，CA 92093系和2名退伍军人埃默里大学学院我们研究了保存良好的阿尔茨海默病(AD)活检材料神经元中细胞骨架组件和膜系统的结构组织。用常规电子显微镜从薄片材料中获得信息，用高压电子显微镜从厚片材料中获得信息。采用立体观察和计算机辅助序列重建技术对皮质神经元胞浆成分之间的三维关系进行可视化。我们观察到AD神经元的几个有趣的超微结构特征。这些现象包括成对螺旋细丝(PHF)与核膜和核糖体的联系，有成对螺旋细丝束的神经元高尔基体与不含成对螺旋细丝的神经元高尔基体分布的差异，以及神经元斑块附近神经元突起微管的异常。
Mark Ellisman 1*, Rama Ranganathan*, Thomas Deerinck*, Stephen Young*, Robert Terry and Suzanne Mirra2 *Laboratory for Neurocytology Neurosciences, UCSD, La Jolla, Administration Medical Center and Medicine, Atlanta, GA 30033 M008, Department of CA 92093 and 2 Veterans Emory University School of We examined the structural organization of cytoskeletal components and membrane systems in neurons of well preserved biopsy material from Alzheimer's disease (AD). Information was obtained from thin sectioned material using conventional electron microscopy and from thick sections with the high voltage electron microscope. Stereo viewing and computer assisted serial reconstruction techniques were employed to visualize three-dimensional relationships among cytoplasmic components of cortical neurons. We observed several interesting ultrastructural features in AD neurons. These in~lude associations of paired helical filaments (PHF) with the membranes of the nuclear envelope and with ribosomes, differences between the distribution of the Golgi apparatus in neurons containing paired helical filament bundles as compared to neurons without these filaments, and abnormalities in the microtubules of neuronal processes in the vicinity of neuritic plaques.
DOI：
10.1073/pnas.82.12.4274
发表时间：
1985-01-01
影响因子：
11.1
作者：
STERNBERGER, NH;STERNBERGER, LA;ULRICH, J
通讯作者：
ULRICH, J