Calcium Wave Propagation Underlying Intercellular Signaling and Coordination of Tissue Responses.
Calcium Wave Propagation Underlying Intercellular Signaling and Coordination of Tissue Responses.
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DOI：
10.1093/function/zqac011
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Corrêa-Velloso JC
中科院分区：
文献类型：
--
作者：
Thomas AP;Corrêa-Velloso JC
胞质Ca 2+浓度（[Ca 2 +] c）的变化在真核生物的四个界中几乎是一个普遍存在的信号，也许在一些原核生物中也是如此。我们对Ca2+信号传导的大部分理解来自于使用分离的细胞制剂的研究，并在单细胞和亚细胞水平上进行了研究。但对分离细胞的研究通常强调了高等生物中细胞放置和结构组织的重要性，其中Ca2+信号通常在细胞之间甚至整个组织中协调。多细胞系统可以通过多种方式对具有协调的Ca2+信号传导的外部刺激做出反应。简单地说，这种刺激本身可以同时直接影响许多细胞，就像内分泌调节一样。但在许多情况下，有限数量的细胞，甚至单个细胞，可能负责细胞外信号的初始检测，然后通过许多细胞间Ca 2+信号传导过程中的任何一个传递到邻近细胞。1作者研究了单个角质形成细胞的光损伤导致活体麻醉小鼠表皮中[Ca 2 +] c辐射波增加的机制。他们的研究结合了通过在耳垂皮肤表面成像直接测量[Ca2+] c与GCaMP6s表达小鼠的多光子显微镜。这种方法使他们能够跟踪激光诱导单细胞损伤后表皮中[Ca2+] c变化的三维分布。初始刺激导致周围角质形成细胞中[Ca2+] c的快速扩散波增加，其逐渐与邻近细胞接触至半径
Changes in cytosolic Ca2+ concentration ([Ca2+] c) serve as an almost ubiquitous signal in organisms across the four kingdoms of Eukaryota, and perhaps in some prokaryotes of Monera as well. Much of our understanding of Ca2+ signaling has come from studies using isolated cell preparations, refined with studies at the single cell and subcellular level. But studies with isolated cells typically obviate the importance of cell placement and structural organization in higher organisms, where Ca2+ signals are often coordinated between cells and even across entire tissues. There are a number of ways in which multicellular systems can respond to an external stimulus with coordinated Ca2+ signaling. At its simplest, that stimulus can itself directly impinge on numerous cells simultaneously, as occurs in endocrine regulation. But in many cases a limited number of cells, or even a single cell, may be responsible for the initial detection of an extracellular signal, which is then conveyed to neighboring cells by any one of a number of intercellular Ca2+ signaling processes.In a study by Donati and coworkers published in the previous issue of Function, 1 the authors investigated the mechanism by which photodamage of a single keratinocyte results in a radiating wave of [Ca2+] c increase in the epidermis of live anesthetized mice. Their study combined direct measurements of [Ca2+] c by imaging at the earlobe skin surface with multiphoton microscopy of GCaMP6s-expressing mice. This approach allowed them to follow the three-dimensional distribution of [Ca2+] c changes in the epidermis following the laser-induced damage of a single cell. The initial stimulus resulted in a rapidly spreading wave of [Ca2+] c increase in the surrounding keratinocytes that progressively engaged adjacent cells to a radius
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DOI：
10.1073/pnas.1616061113
发表时间：
2016-11-15
影响因子：
11.1
作者：
Ceriani, Federico;Pozzan, Tullio;Mammano, Fabio
通讯作者：
Mammano, Fabio
影响因子：
15.9
作者：
Parthasarathi, Kaushik;Ichimura, Hideo;Bhattacharya, Jahar
通讯作者：
Bhattacharya, Jahar
影响因子：
3.2
作者：
Sanderson MJ
通讯作者：
Sanderson MJ
影响因子：
5.5
作者：
Gaspers, Lawrence D.;Pierobon, Nicola;Thomas, Andrew P.
通讯作者：
Thomas, Andrew P.
DOI：
10.1093/function/zqab002
发表时间：
2021
期刊：
Function (Oxford, England)
影响因子：
--
作者：
Gaspers LD;Thomas AP;Hoek JB;Bartlett PJ
通讯作者：
Bartlett PJ